A Combined Healthy Lifestyle Score in Relation to Glioma: A Case-Control Study. (7th June 2021)

• Record Type: Journal Article
• Authors: Ebrahimpour-Koujan, Soraiya; Shayanfar, Mehdi; Mohammad-Shirazi, Minoo; Sharifi, Giuve; Esmaillzadeh, Ahmad
• Is Part Of: Current developments in nutrition. Volume 5(2021)Supplement 2
• Page Start: 267
• Page End: 267
• Publication Date: 2021-06-07
• Subjects: Nutrition -- Periodicals; Nutritional Physiological Phenomena; Nutrition; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 612.3
• DOI: 10.1093/cdn/nzab036_009
• Languages: English
• ISSNs: 2475-2991

Abstract

Abstract: Objectives: The evidence on the association between adherence to a healthy lifestyle and risk of glioma are scare. This is particularly relevant to Middle Eastern countries where lifestyle factors are different from other parts of the world. This case-control study was, therefore, conducted to investigate the association between adherence to a healthy lifestyle and odds of glioma among adults. Methods: Totally, 128 newly diagnosed glioma cases and 256 age- and sex-matched controls were recruited in this hospital-based case-control study. Dietary intakes were examined by the use of a 126-item validated FFQ. International Physical Activity Questionnaire (IPAQ) was used for measuring physical activity of participants. To construct a healthy lifestyle score (HLS), data from dietary intakes, physical activity and BMI were used. Subjects in the low risk categories of the mentioned components received the score of 1, otherwise they received the score of 0. The final HLS was computed through summing up the scores of components. Results: After adjustment for age and sex, we found that individuals with the highest HLS score were 55% less likely to have glioma compared with those with the lowest score (OR: 0.45; 95% CI: 0.22, 0.92). Additional controlling for other potential confounders made the association stronger (OR: 0.28; 95%CI: 0.12, 0.66). In terms of individual components of healthy lifestyle score, subjects with a healthy diet had 54% lower odds of glioma than those with a non-healthy diet (OR: 0.46; 95%CI: 0.26, 0.80). No significant associations were seen between physical activity level or BMI status and glioma. Conclusions: We found evidence indicating that adherence to a healthy lifestyle, in particular a healthy diet, was associated with a lower odds of glioma. Prospective cohort studies are needed to confirm these findings. Funding Sources: The financial support for this study comes from Tehran University of Medical Sciences, Tehran, Iran.