Tailored Dietary Approach for Individuals With Migraine. (7th June 2021)

• Record Type: Journal Article
• Authors: Linke, Susan; Zarini, Gustavo; McLean, Michael; Hogan, Joan; Hogan, Patrick; Patenaude, Jan
• Is Part Of: Current developments in nutrition. Volume 5(2021)Supplement 2
• Page Start: 849
• Page End: 849
• Publication Date: 2021-06-07
• Subjects: Nutrition -- Periodicals; Nutritional Physiological Phenomena; Nutrition; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 612.3
• DOI: 10.1093/cdn/nzab047_012
• Languages: English
• ISSNs: 2475-2991

Abstract

Abstract: Objectives: We examined the therapeutic potential of the Lifestyle Eating and Performance (LEAP) program to improve global symptom scores for frequency and severity in individuals with migraine. Methods: The retrospective study analyzed de-identified data from individuals (n = 40) suffering from migraine counseled by dietitians in private practices. The LEAP program is based on the oligoantigenic diet principles and is built on selecting less immune reactive foods and chemicals from the Leukocyte Activation Assay-MRT (LAA-MRT) blood results. The LAA-MRT was conducted using Flow Cytometry Systems to characterize and quantify the volumetric change in each white blood cells population after being challenged and incubated with 150 food and chemical antigens. BMI was calculated as weight in kg/height in m 2 . A global symptom survey was used to evaluate the frequency and severity of 13 domains of symptoms. The survey was quantified on a scale of 0 - 4, ranging from 0 to 248 points, with a higher score signifying a less desirable health state. Descriptive statistics and linear mixed models were performed using the SPSS V25.0. The study received approval from an independent Institutional Review Board (IRB). Results: Thirty-five (87.5%) were female, had a mean age 42.1 ± 11.3 years, and a BMI of 28.2 ± 7.3 kg/m 2 . The average follow-up time seen by the dietitians was 82.3 ± 71.0 days. Linear mixed models showed a significant decrease in mean (standard error) overall global symptom scores pre- versus post-intervention (72.1 ± 4.5 vs. 31.5 ± 4.5, P < 0.001) and for each of the 13 domains [constitutional (10.1 ± 0.7 vs. 4.9 ± 0.6, P < 0.001); emotional/mental (9.5 ± 0.8 vs. 4.7 ± 0.7, P < 0.001); head/ears (5.2 ± 0.5 vs. 2.1 ± 0.3, P < 0.001); skin (2.9 ± 0.4 vs. 1.4 ± 0.3, P = 0.002); nasal/sinus (6.4 ± 0.8 vs. 2.5 ± 0.4, P < 0.001); mouth/throat (3.2 ± 0.5 vs. 1.1 ± 0.3, P < 0.001); lungs (1.9 ± 0.4 vs. 0.8 ± 0.2, P = 0.020); eyes (4.3 ± 0.5 vs. 1.9 ± 0.4, P < 0.001); genitourinary (1.3 ± 0.3 vs. 0.6 ± 0.1, P = 0.013); musculoskeletal (8.0 ± 0.8 vs. 3.9 ± 0.6, P < 0.001); cardiovascular (1.1 ± 0.7 vs. 0.4 ± 0.1, P < 0.001); digestive (12.4 ± 1.2 vs. 5.3 ± .9, P < 0.001); and weight management (5.5 ± 0.7 vs. 1.8 ± 0.3, P < 0.001)]. Conclusions: The findings from this study highlight the role of LEAP program as a tailored dietary approach that alleviated overall symptoms in individuals with migraine. Funding Sources: Oxford Biomedical Technologies, Inc.