Effects of Obesity and Low and High Isoflavones in Soy Protein Concentrate Diet on Liver Steatosis. (7th June 2021)

• Record Type: Journal Article
• Authors: Kozaczek, Melisa; Korourian, Soheila; Spary, Beverly; Irby, David; Hakkak, Reza
• Is Part Of: Current developments in nutrition. Volume 5(2021)Supplement 2
• Page Start: 339
• Page End: 339
• Publication Date: 2021-06-07
• Subjects: Nutrition -- Periodicals; Nutritional Physiological Phenomena; Nutrition; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 612.3
• DOI: 10.1093/cdn/nzab037_049
• Languages: English
• ISSNs: 2475-2991

Abstract

Abstract: Objectives: To examine the role of isoflavones levels in soy protein diets on protection against Non-Alcoholic Fatty Liver Disease (NAFLD) in obese rat model (8 weeks of feeding). Methods: 42 six-week old lean ( n = 21) and obese ( n = 21) Zucker rats were randomly assigned to one of 3 dietary groups: casein diet (C = control), soy protein with low isoflavones (LIF), or soy protein with high isoflavones (HIF) for 8 weeks ( n = 7 rats/group). Rats were weighed twice weekly. After 8 weeks, all rats were sacrificed and livers taken for histopathological analysis. Results: Obese rats gained significantly more weight ( P < 0.0001) than lean rats for all three diet groups, with no significant difference between obese (O) LIF vs. OHIF groups ( P = 0.19). Body weight was higher in OHIF (717 g) than in OLIF and OC (694 and 620, respectively). No significant difference between LC, LLIF and LHIF ( P between 0.3 and 0.6) was found. Liver steatosis scores were significantly higher in obese rats compared to lean rats ( P < 0.001). In addition, differences in the steatosis scores between OC vs. OHIF ( P < 0.0001) were more significant than differences between OC vs. OLIF ( P = 0.01), and OLIF vs. OHIF ( P = 0.01) groups, showing the protective effect against liver steatosis exerted by soy protein concentrate with higher isoflavones. Conclusions: We found that soy protein concentrate protects against liver steatosis and protection is more significant with higher concentration of isoflavones. Funding Sources: USDA.