Hepatitis A and B vaccine uptake and immunisation among men who have sex with men seeking PrEP: a substudy of the ANRS IPERGAY trial. (8th December 2022)

• Record Type: Journal Article
• Authors: Le Turnier, Paul; Charreau, Isabelle; Gabassi, Audrey; Carette, Diane; Cotte, Laurent; Pialoux, Gilles; Tremblay, Cécile; Spire, Bruno; Chaix, Marie-Laure; Meyer, Laurence; Capitant, Catherine; Delaugerre, Constance; Raffi, François; Molina, Jean-Michel
• Other Names: author non-byline.; Pintado C author non-byline.; Loze B author non-byline.; Delaugerre C author non-byline.; Charbonneau P author non-byline.; Gatey C author non-byline.; Ponscarme D author non-byline.; Penot P author non-byline.; Niedbalski L author non-byline.; Veron R author non-byline.; Delgado J author non-byline.; Dalle E author non-byline.; Parlier S author non-byline.; Madelaine I author non-byline.; Fonsart J author non-byline.; Danet M author non-byline.; Mahjoub N author non-byline.; Mezreb N author non-byline.; Moudachirou K author non-byline.; Morel S author non-byline.; Conort G author non-byline.; Lorho F author non-byline.; Meunier M author non-byline.; Rozenbaum W author non-byline.; Molina JM author non-byline.; Chas J author non-byline.; Monfort C author non-byline.; Foucoin J author non-byline.; Boissavy B author non-byline.; Cousseau S author non-byline.; Huon S author non-byline.; Danet M author non-byline.; Djessima A author non-byline.; Berrebi V author non-byline.; Adda A author non-byline.; le Nagat S author non-byline.; Zarka L author non-byline.; Berdougo J author non-byline.; Pialoux G author non-byline.; Chidiac C author non-byline.; Mzoughi N author non-byline.; Clement F author non-byline.; Decouty A author non-byline.; Chapolard C author non-byline.; Godinot M author non-byline.; Adouard-groslafeige C author non-byline.; Koffi J author non-byline.; Pansu A author non-byline.; Becker A author non-byline.; Pailhes S author non-byline.; Bonnet F author non-byline.; Jeanblanc F author non-byline.; Brochier C author non-byline.; Teruin X author non-byline.; Rouby S author non-byline.; Gilly L author non-byline.; Cotte L author non-byline.; Beauvais C author non-byline.; Arlotto P author non-byline.; Fortin C author non-byline.; Talbot A author non-byline.; Chamberland A author non-byline.; McKenzie A author non-byline.; Blanchette M author non-byline.; Rousseau R author non-byline.; Montheuth K author non-byline.; Thompson D author non-byline.; Morin M author non-byline.; Wainberg M author non-byline.; Tremblay C author non-byline.; Etienne C author non-byline.; Tolonin F author non-byline.; Breaud S author non-byline.; Péchenot V author non-byline.; Bagge S author non-byline.; Cepitelli T author non-byline.; Roger PM author non-byline.; Rosenthal E author non-byline.; Cua E author non-byline.; Cheret A author non-byline.; Cornavin P author non-byline.; Vandamme S author non-byline.; Lambec J author non-byline.; Dumon N author non-byline.; Leclanche O author non-byline.; Huleux T author non-byline.; Biekre R author non-byline.; Robineau O author non-byline.; Melliez H author non-byline.; Bazus H author non-byline.; Pasquet A author non-byline.; Bernaud C author non-byline.; Besnier M author non-byline.; Bonnet B author non-byline.; Hall N author non-byline.; Cavellec M author non-byline.; Hue H author non-byline.; Larmet L author non-byline.; Colas M author non-byline.; Choquet R author non-byline.; Raffi F author non-byline.; Molina Jean-Michel author non-byline.; Wainberg Mark author non-byline.; Trottier Benoit author non-byline.; Tremblay Cécile author non-byline.; Baril JeanGuy author non-byline.; Pialoux Gilles author non-byline.; Cotte Laurent author non-byline.; Chéret Antoine author non-byline.; Pasquet Armelle author non-byline.; Cua Eric author non-byline.; Besnier Michel author non-byline.; Rozenbaum Willy author non-byline.; Chidiac Christian author non-byline.; Delaugerre Constance author non-byline.; Bajos Nathalie author non-byline.; Timsit Julie author non-byline.; Peytavin Gilles author non-byline.; Fonsart Julien author non-byline.; Durand-Zaleski Isabelle author non-byline.; Meyer Laurence author non-byline.; Aboulker Jean-Pierre author non-byline.; Spire Bruno author non-byline.; Suzan-Monti Marie author non-byline.; Girard Gabriel author non-byline.; Castro Daniela Rojas author non-byline.; Préau Marie author non-byline.; Morin Michel author non-byline.; Thompson David author non-byline.; Capitant Catherine author non-byline.; Marchand Lucie author non-byline.; Doré Véronique author non-byline.; Simon Marie-Christine author non-byline.; Charreau Isabelle author non-byline.; Otis Joanne author non-byline.; Lert France author non-byline.; Diallo Alpha author non-byline.; Gibowski Séverine author non-byline.; Rabian Cecile author non-byline.; Costagliola Dominique author non-byline.; Yazdanpanah Yazdan author non-byline.; Nguyen Vinhh-Kim author non-byline.; Taburet AnneMarie author non-byline.; Taéron Corinne author non-byline.; Le Gall JM author non-byline.; Morel S author non-byline.; Pechenot V author non-byline.; Bagge S author non-byline.; Djessima Taba A author non-byline.; Danet M author non-byline.; Moudachirou K author non-byline.; Dos Santos B author non-byline.; Lambec J author non-byline.; Rouby S author non-byline.; Teruin X author non-byline.; Dumon N author non-byline.; Coquelin V author non-byline.; Brunet P author non-byline.; Gilly L author non-byline.; Cepitelli T author non-byline.; Porion R author non-byline.; Rojas Castro D author non-byline.; Spire B author non-byline.; Meyer L author non-byline.; Capitant C author non-byline.; Charreau I author non-byline.; Netzer E author non-byline.; Leturque N author non-byline.; Binesse J author non-byline.; Foubert V author non-byline.; Saouzanet M author non-byline.; Euphrasie F author non-byline.; Guillon B author non-byline.; Saïdi Y author non-byline.; Aboulker JP author non-byline.; Spire B author non-byline.; Suzan M author non-byline.; Cattin G author non-byline.; Demoulin B author non-byline.; Sagaon-Teyssier L author non-byline.; Lorente N author non-byline.;
• Is Part Of: Sexually transmitted infections. Volume 99:issue 2(2023)
• Page Start: 140
• Page End: 142
• Publication Date: 2022-12-08
• Subjects: VACCINATION -- HEPATITIS A -- HEPATITIS B -- Pre-Exposure Prophylaxis; Sexually transmitted diseases -- Periodicals; HIV infections -- Periodicals; 616.951005
• DOI: 10.1136/sextrans-2022-055634
• Languages: English
• ISSNs: 1368-4973

Abstract

Abstract : Vaccination against hepatitis A virus (HAV) and hepatitis B virus (HBV) is recommended in men who have sex with men (MSM). We assessed HAV and HBV vaccine uptake in the non-immune participants and their immunisation during follow-up of the ANRS IPERGAY (Intervention Préventive de l'Exposition aux Risques avec et pour les Gays) pre-exposure prophylaxis (PrEP) trial. During the ANRS IPERGAY trial among MSM (NCT 01473472), vaccination against HAV and HBV was offered free of charge to all non-immune participants at baseline. We assessed anti-HAV IgGs and anti-hepatitis B surface (HBs) antibodies (Abs) at baseline, 1–3 months after each vaccine dose and on the last follow-up visit. Vaccination uptake and immunisation were analysed in non-immune participants with at least 6 months of follow-up after the 1st vaccine dose. A total of 427 MSM with a median age of 34.8 years were analysed. Median follow-up was 2.2 years (Q1–Q3, 1.6–2.9). Absence of anti-HAV IgG at baseline (50.4%, 215/427) was associated with younger age (p=0.0001). Among HAV non-immune participants, 96.1% (197/205) received one or more vaccine doses and 91.0% (172/189) received two vaccine doses. Among HBV non-immune participants, 97.6 % (81/83) received one or more vaccine doses and 78.4% (58/74) received three doses. On the last-visit sample, anti-HAV IgG and anti-HBs Abs were respectively detected in 94.8% (95% CI 90.0% to 97.7%) and 79.6% (95% CI 66.5% to 89.4%) of participants with complete vaccination and in 80.0% (95% CI 51.9% to 95.7%) and 40.0% (95% CI 16.3% to 67.7%) of participants with incomplete vaccination. Vaccine acceptability against HAV and HBV infections was very high in MSM starting PrEP. Immunisation was high in participants with a full vaccination scheme. Physicians must consider PrEP visits as major opportunities to propose and complete HAV and HBV vaccination in at-risk non-immune subjects.