Successful reperfusion in relation to the number of passes: comparing outcomes of first pass expanded Treatment In Cerebral Ischemia (eTICI) 2B with multiple-pass eTICI 3. (27th January 2022)

• Record Type: Journal Article
• Authors: Bruggeman, Agnetha A E; Kappelhof, Manon; den Hartog, Sanne J; Burke, James F; Berkhemer, Olvert A; van Es, Adriaan C G M; van Zwam, Wim H; Dippel, Diederik W J; Coutinho, Jonathan M; Marquering, Henk A; Majoie, Charles B L M; Emmer, Bart J
• Other Names: author non-byline.; Dippel Diederik WJ author non-byline.; Lugt Aad van der author non-byline.; Majoie Charles BLM author non-byline.; Roos Yvo BWEM author non-byline.; Oostenbrugge Robert J van author non-byline.; Zwam Wim H van author non-byline.; Boiten Jelis author non-byline.; Vos Jan Albert author non-byline.; Jansen Ivo GH author non-byline.; Mulder Maxim JHL author non-byline.; Goldhoorn Robert-Jan B author non-byline.; Compagne Kars CJ author non-byline.; Kappelhof Manon author non-byline.; Brouwer Josje author non-byline.; Hartog Sanne J den author non-byline.; Hinsenveld Wouter H author non-byline.; Roozenbeek Bob author non-byline.; Es Adriaan CGM van author non-byline.; Emmer Bart J author non-byline.; Coutinho Jonathan M author non-byline.; Schonewille Wouter J author non-byline.; Wermer Marieke JH author non-byline.; Walderveen Marianne AA van author non-byline.; Staals Julie author non-byline.; Hofmeijer Jeannette author non-byline.; Martens Jasper M author non-byline.; Nijeholt Geert Lycklama author non-byline.; Bruijn Sebastiaan F de author non-byline.; Dijk Lukas C van author non-byline.; Bart van der Worp H author non-byline.; Lo Rob H author non-byline.; Dijk Ewoud J van author non-byline.; Boogaarts Hieronymus D author non-byline.; de Vries J author non-byline.; Kort Paul LM de author non-byline.; Tuijl Julia van author non-byline.; Peluso Jo P author non-byline.; Fransen Puck author non-byline.; Berg Jan SP van den author non-byline.; Hasselt Boudewijn AAM van author non-byline.; Aerden Leo AM author non-byline.; Dallinga René J author non-byline.; Uyttenboogaart Maarten author non-byline.; Eschgi Omid author non-byline.; Bokkers Reinoud PH author non-byline.; Schreuder Tobien HCML author non-byline.; Heijboer Roel JJ author non-byline.; Keizer Koos author non-byline.; Yo Lonneke SF author non-byline.; Hertog Heleen M den author non-byline.; Bulut Tomas author non-byline.; Brouwers Paul JAM author non-byline.; Walderveen Marianne AA van author non-byline.; Sprengers Marieke ES author non-byline.; Jenniskens Sjoerd FM author non-byline.; Berg René van den author non-byline.; Yoo Albert J author non-byline.; Beenen Ludo FM author non-byline.; Postma Alida A author non-byline.; Roosendaal Stefan D author non-byline.; Kallen Bas FW van der author non-byline.; Wijngaard Ido R van den author non-byline.; Yo Lonneke SF author non-byline.; Bot Joost author non-byline.; Doormaal Pieter-Jan van author non-byline.; Meijer Anton author non-byline.; Ghariq Elyas author non-byline.; Bokkers Reinoud PH author non-byline.; Proosdij Marc P van author non-byline.; Menno Krietemeijer G author non-byline.; Peluso Jo P author non-byline.; Boogaarts Hieronymus D author non-byline.; Lo Rob author non-byline.; Dinkelaar Wouter author non-byline.; Appelman Auke PA author non-byline.; Hammer Bas author non-byline.; Pegge Sjoert author non-byline.; Hoorn Anouk van der author non-byline.; Vinke Saman author non-byline.; Zwenneke Flach H author non-byline.; Lingsma Hester F author non-byline.; Ghannouti Naziha el author non-byline.; Sterrenberg Martin author non-byline.; Pellikaan Wilma author non-byline.; Sprengers Rita author non-byline.; Elfrink Marjan author non-byline.; Simons Michelle author non-byline.; Vossers Marjolein author non-byline.; Meris Joke de author non-byline.; Vermeulen Tamara author non-byline.; Geerlings Annet author non-byline.; Vemde Gina van author non-byline.; Simons Tiny author non-byline.; Messchendorp Gert author non-byline.; Nicolaij Nynke author non-byline.; Bongenaar Hester author non-byline.; Bodde Karin author non-byline.; Kleijn Sandra author non-byline.; Lodico Jasmijn author non-byline.; Droste Hanneke author non-byline.; Wollaert Maureen author non-byline.; Verheesen Sabrina author non-byline.; Jeurrissen D author non-byline.; Bos Erna author non-byline.; Drabbe Yvonne author non-byline.; Sandiman Michelle author non-byline.; Aaldering Nicoline author non-byline.; Zweedijk Berber author non-byline.; Vervoort Jocova author non-byline.; Ponjee Eva author non-byline.; Romviel Sharon author non-byline.; Kanselaar Karin author non-byline.; Barning Denn author non-byline.; Venema Esmee author non-byline.; Chalos Vicky author non-byline.; Geuskens Ralph R author non-byline.; Straaten Tim van author non-byline.; Ergezen Saliha author non-byline.; Harmsma Roger RM author non-byline.; Muijres Daan author non-byline.; Jong Anouk de author non-byline.; Berkhemer Olvert A author non-byline.; Boers Anna MM author non-byline.; Huguet J author non-byline.; Groot PFC author non-byline.; Mens Marieke A author non-byline.; Kranendonk Katinka R van author non-byline.; Treurniet Kilian M author non-byline.; Tolhuisen Manon L author non-byline.; Alves Heitor author non-byline.; Weterings Annick J author non-byline.; Kirkels Eleonora LF author non-byline.; Voogd Eva JHF author non-byline.; Schupp Lieve M author non-byline.; Collette Sabine L author non-byline.; Groot Adrien ED author non-byline.; LeCouffe Natalie E author non-byline.; Konduri Praneeta R author non-byline.; Prasetya Haryadi author non-byline.; Arrarte-Terreros Nerea author non-byline.; Ramos Lucas A author non-byline.;
• Is Part Of: Journal of neurointerventional surgery. Volume 15:Number 2(2023)
• Page Start: 120
• Page End: 126
• Publication Date: 2022-01-27
• Subjects: stroke -- thrombectomy -- intervention; Nervous system -- Surgery -- Periodicals; Cerebrovascular disease -- Surgery -- Periodicals; 617.48
• DOI: 10.1136/neurintsurg-2021-018465
• Languages: English
• ISSNs: 1759-8478

Abstract

Abstract : Background: Higher expanded Treatment In Cerebral Ischemia (eTICI) reperfusion scores after endovascular treatment (EVT) are associated with better outcomes. However, the influence of the number of passes on this association is unclear. We aimed to compare outcomes of single-pass good reperfusion (eTICI 2B) with multiple-pass excellent/complete reperfusion (eTICI 2C/3) in daily clinical practice. Methods: We compared outcomes of patients in the MR CLEAN Registry with good reperfusion (eTICI 2B) in a single pass to those with excellent/complete reperfusion (eTICI 2C/3) in multiple passes. Regression models were used to investigate the association of single-pass eTICI 2B versus multiple-pass eTICI 2C/3 reperfusion with 90-day functional outcome (modified Rankin Scale (mRS)), functional independence (mRS 0–2), per-procedural complications and safety outcomes. Results: We included 699 patients: 178 patients with single-pass eTICI 2B, and 242 and 279 patients with eTICI 2C/3 after 2 and ≥3 passes, respectively. Patients with eTICI 2C/3 after 2 or ≥3 passes did not achieve significantly better functional outcomes compared with patients with single-pass eTICI 2B (adjusted common OR (acOR) 1.06, 95% CI 0.75 to 1.50 and acOR 0.88, 95% CI 0.74 to 1.05 for 90-day mRS, and adjusted OR (aOR) 1.24, 95% CI 0.78 to 1.97 and aOR 0.79, 95% CI 0.52 to 1.22 for functional independence). Conclusions: Our results did not show better outcomes for patients who achieved eTICI 2C/3 in multiple, that is, two or more, passes when compared with patients with single-pass eTICI 2B. However, this concerns observational data. Further research is necessary to investigate the per-pass effect in relation to reperfusion and functional outcome.