Severe acute kidney injury as presentation of Burkitt's lymphoma. (26th April 2016)

• Record Type: Journal Article
• Authors: ter Haar, Eva; Labarque, Veerle; Tousseyn, Thomas; Mekahli, Djalila
• Is Part Of: BMJ case reports. Volume 2016
• Publication Date: 2016-04-26
• Subjects: Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2016-214780
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : We discuss a case of acute kidney injury (AKI) at a very young age caused by primary lymphomatous renal infiltration due to Burkitt's lymphoma and analyse the literature on this rare condition. At presentation, clinical examination showed impressive bilateral nephromegaly and hypertension. Blood analysis indicated severe AKI, mild anaemia and normal serum electrolytes. There were no signs of tumour lysis syndrome. Urine sediment was normal, with neither haematuria nor proteinuria. Abdominal ultrasound demonstrated bilateral renal enlargement (+12 SD), with increased corticomedullar differentiation. MRI demonstrated the presence of a homogenous renal enlargement with features of an infiltrative lesion. Ultimately, microscopic and immunohistochemical analysis of the renal biopsy confirmed the diagnosis of Burkitt's lymphoma. Early and aggressive therapy is the key to ensure a good outcome.