Extraction of cardiac-related signals from a suprasternal pressure sensor during sleep. (1st March 2023)

• Record Type: Journal Article
• Authors: Cerina, Luca; Papini, Gabriele B; Fonseca, Pedro; Overeem, Sebastiaan; van Dijk, Johannes P; Vullings, Rik
• Is Part Of: Physiological measurement. Volume 44:Number 3(2023)
• Publication Date: 2023-03-01
• Subjects: sleep disordered breathing -- polysomnography -- sleep -- heart rate -- suprasternal notch pressure -- respiratory effort -- cardiogenic oscillations; Physiology -- Measurement -- Periodicals; Patient monitoring -- Periodicals; 612
• DOI: 10.1088/1361-6579/acb12b
• Languages: English
• ISSNs: 0967-3334

Abstract

Abstract: Objective. The accurate detection of respiratory effort during polysomnography is a critical element in the diagnosis of sleep-disordered breathing conditions such as sleep apnea. Unfortunately, the sensors currently used to estimate respiratory effort are either indirect and ignore upper airway dynamics or are too obtrusive for patients. One promising alternative is the suprasternal notch pressure (SSP) sensor: a small element placed on the skin in the notch above the sternum within an airtight capsule that detects pressure swings in the trachea. Besides providing information on respiratory effort, the sensor is sensitive to small cardiac oscillations caused by pressure perturbations in the carotid arteries or the trachea. While current clinical research considers these as redundant noise, they may contain physiologically relevant information. Approach. We propose a method to separate the signal generated by cardiac activity from the one caused by breathing activity. Using only information available from the SSP sensor, we estimate the heart rate and track its variations, then use a set of tuned filters to process the original signal in the frequency domain and reconstruct the cardiac signal. We also include an overview of the technical and physiological factors that may affect the quality of heart rate estimation. The output of our method is then used as a reference to remove the cardiac signal from the original SSP pressure signal, to also optimize the assessment of respiratory activity. We provide a qualitative comparison against methods based on filters with fixed frequency cutoffs. Main results. In comparison with electrocardiography (ECG)-derived heart rate, we achieve an agreement error of 0.06 ± 5.09 bpm, with minimal bias drift across the measurement range, and only 6.36% of the estimates larger than 10 bpm. Significance. Together with qualitative improvements in the characterization of respiratory effort, this opens the development of novel portable clinical devices for the detection and assessment of sleep disordered breathing.