PH and GSH dual-responsive drug-controlled nanomicelles for breast cancer treatment. (22nd February 2023)

• Record Type: Journal Article
• Authors: Xu, Jingjing; Tang, Xianjiao; Yang, Xiaojing; Zhao, Mei-Xia
• Is Part Of: Biomedical materials. Volume 18:Number 2(2023)
• Publication Date: 2023-02-22
• Subjects: tumor -- dual-responsive -- nanomicelles -- pH -- GSH; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1088/1748-605X/acb7bb
• Languages: English
• ISSNs: 1748-6041

Abstract

Abstract: We developed a pH/glutathione (GSH) dual-responsive smart nano-drug delivery system to achieve targeted release of a chemotherapeutic drug at breast tumor site. Doxorubicin (DOX) was linked to polyethylene glycol (PEG) through cis-aconitic anhydride (CA) and disulfide bonds (SS) to obtain the PEG-SS-CA-DOX prodrug, which spontaneously assembled into nanomicelles with a particle size of 48 ± 0.45 nm. PEG-SS-CA-DOX micelles achieved an efficient and rapid release of DOX under dual stimulation by weak acidic pH and high GSH content of tumors, with the release amount reaching 88.0% within 48 h. Cellular uptake experiments demonstrated that PEG-SS-CA-DOX micelles could efficiently transport DOX into cells and rapidly release it in the tumor microenvironment. In addition, in vivo antitumor experiments showed that PEG-SS-CA-DOX had a high inhibition rate of 70% against 4T1 breast cancer cells along with good biosafety. In conclusion, dual-responsive smart nanomicelles can achieve tumor-targeted drug delivery and specific drug release, thus improving therapeutic efficacy of drugs.