Diagnostic accuracy of the cancer ratio for the prediction of malignant pleural effusion: evidence from a validation study and meta-analysis. (1st January 2021)

• Record Type: Journal Article
• Authors: Zhang, Ying; Li, Xiaoou; Liu, Junhui; Hu, Xueru; Wan, Chun; Zhang, Rui; Shen, Yongchun
• Is Part Of: Annals of medicine. Volume 53:Number 1(2021)
• Page Start: 558
• Page End: 566
• Publication Date: 2021-01-01
• Subjects: Malignant pleural effusion -- cancer ratio -- carcinoembryonic antigen -- diagnosis -- meta-analysis; Medicine -- Periodicals; 610
• DOI: 10.1080/07853890.2021.1906943
• Languages: English
• ISSNs: 0785-3890

Abstract

Abstract: Objective: This study aimed to assess the diagnostic accuracy of serum LDH to pleural ADA ratio (cancer ratio, CR)for malignant pleural effusion (MPE) through an original study and meta-analysis. Methods: We retrospectively collected data from 145 patients with MPE and 117 cases of benign pleural effusions (BPE). The diagnostic performance of CR and a typical biomarker of MPE, carcinoembryonic antigen (CEA), were analysed using the receiver operating characteristic (ROC) curves and the area under the curve (AUC) as a measure of accuracy. The overall diagnostic accuracy of CR was summarised by a standard diagnostic meta-analysis. Results: Significantly higher CR and pleural CEA values were observed in the MPE patients than in the BPE patients. At a cut-off value of 14.97, CR showed high sensitivity (0.91), low specificity (0.67), and high AUC (0.85). The combination of CEA and CR increased the AUC to 0.98. The meta-analysis included seven studies involving 2, 078 patients. The pooled values for sensitivity, specificity, positive/negative likelihood ratio, and diagnostic odds ratio of CR were 0.96, 0.88, 7.70, 0.05, and 169, respectively. The AUC of the summary ROC of CR was 0.98. Conclusion: CR has a high diagnostic accuracy for predicting MPE, especially when used in combination with pleural CEA.