Feasibility and Performance of Self-Collected Nasal Swabs for Detection of Influenza Virus, Respiratory Syncytial Virus, and Human Metapneumovirus. (18th January 2021)

• Record Type: Journal Article
• Authors: Suntarattiwong, Piyarat; Mott, Joshua A; Mohanty, Sarita; Sinthuwattanawibool, Chalinthorn; Srisantiroj, Nattinee; Patamasingh Na Ayudhaya, Orada; Klungthong, Chonticha; Fernandez, Stefan; Kim, Lindsay; Hunt, Danielle; Hombroek, Danielle; Brummer, Tana; Chotpitayasunondh, Tawee; Dawood, Fatimah S; Kittikraisak, Wanitchaya
• Is Part Of: Journal of infectious diseases. Volume 224:Number 5(2021)
• Page Start: 831
• Page End: 838
• Publication Date: 2021-01-18
• Subjects: feasibility -- performance -- self-collection -- nasal swab -- influenza -- RSV -- hMPV -- pregnant woman -- Thailand; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab023
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Background: We assessed performance of participant-collected midturbinate nasal swabs compared to study staff-collected midturbinate nasal swabs for the detection of respiratory viruses among pregnant women in Bangkok, Thailand. Methods: We enrolled pregnant women aged ≥18 years and followed them throughout the 2018 influenza season. Women with acute respiratory illness self-collected midturbinate nasal swabs at home for influenza viruses, respiratory syncytial viruses (RSV), and human metapneumoviruses (hMPV) real-time RT-PCR testing and the study nurse collected a second midturbinate nasal swab during home visits. Paired specimens were processed and tested on the same day. Results: The majority (109, 60%) of 182 participants were 20–30 years old. All 200 paired swabs had optimal specimen quality. The median time from symptom onsets to participant-collected swabs was 2 days and to staff-collected swabs was also 2 days. The median time interval between the 2 swabs was 2 hours. Compared to staff-collected swabs, the participant-collected swabs were 93% sensitive and 99% specific for influenza virus detection, 94% sensitive and 99% specific for RSV detection, and 100% sensitive and 100% specific for hMPV detection. Conclusions: Participant-collected midturbinate nasal swabs were a valid alternative approach for laboratory confirmation of influenza-, RSV-, and hMPV-associated illnesses among pregnant women in a community setting. Abstract : Participant-collected midturbinate nasal swabs were a valid alternative approach for laboratory confirmation of influenza-, RSV-, and hMPV-associated illnesses among pregnant women in a community setting.