Incidence and Impact of Parvovirus B19 Infection in Seronegative Solid Organ Transplant Recipients. (17th January 2021)

• Record Type: Journal Article
• Authors: Rezahosseini, Omid; Ekenberg, Christina; Møller, Dina Leth; Sørensen, Søren Schwartz; Wareham, Neval Ete; Perch, Michael; Gustafsson, Finn; Rasmussen, Allan; Kirkby, Nikolai; Reekie, Joanne; Lundgren, Jens; Nielsen, Susanne Dam
• Is Part Of: Journal of infectious diseases. Volume 224:Number 5(2021)
• Page Start: 865
• Page End: 869
• Publication Date: 2021-01-17
• Subjects: organ transplant -- parvovirus B19 -- human -- polymerase chain reaction -- incidence; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab024
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Routine monitoring of parvovirus B19 (B19V) the first 6 months posttransplantation was performed in 241 seronegative solid organ transplant (SOT) recipients. Incidence rates during the first month and the second to sixth months posttransplantation were 1.2 (95% confidence interval [CI], .33–3.2) and 0.21 (95% CI, .06–.57) per 100 recipients per month, respectively. Of the 6 SOT recipients with positive B19V polymerase chain reaction, 3 (50%) were admitted to hospital and 2 (33%) were treated with intravenous immunoglobulin. Thus, routine monitoring of B19V in seronegative SOT recipients may not be necessary. Targeted screening 1 month posttransplantation and screening upon clinical suspicion could be an alternative strategy. Abstract : The incidence rate of B19V infection in seronegative solid organ transplant (SOT) recipients was low and routine monitoring of B19V in seronegative SOT recipients may not be necessary. Targeted screening 1 month posttransplantation combined with screening upon clinical suspicion could be an alternative strategy.