Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population. (14th February 2023) - Zhang, Shaoyuan
Abstract : Introduction . LAMA1, also known as laminin subunit α 1, is a member of the laminin family, which is widely reported to be a key basement membrane molecule that affects various biological activities and is associated with many kinds of diseases. We aimed to investigate the association between LAMA1 single-nucleotide polymorphisms and the occurrence and progression of esophageal squamous cell carcinoma in the Chinese population. Method . 2, 186 participants were collected retrospectively between October 2008 and January 2017, including 1, 043 ESCC patients and 1, 143 noncancer patients. A 2 mL blood sample was obtained intravenously for the LDR for SNP analysis. The 6 SNP loci of LAMA1 were selected and examined. We analyzed the association of several genetic models of 6 LAMA1 SNP loci, sex, age, smoking and drinking status, and the occurrence of esophageal squamous cell carcinoma. Results . In the rs62081531 G > A locus, genotype GA was a protective factor for ESCC compared with GG (OR: 0.830, P = 0.046 ), especially among the younger and nondrinkers. At rs607230 T > C, genotype TC was linked with a lower risk of ESCC compared with TT. (OR: 0.613, P = 0.034 ). Haplotype Frequencies revealed that Ars62081531 Grs621993 Ars539713 Trs566655 Ars73938538 Crs607230 (OR: 0.803, P = 0.028 ) and Grs62081531 Grs621993 Ars539713 Trs566655 Crs73938538 Crs607230 (OR: 0.679, P = 0.010 ) were strongly associated with lower susceptibility of ESCC. Conclusion . The LAMA1 rs62081531, rs539713, rs566655, and rs607230 polymorphisms were demonstrated to be related to susceptibility to ESCC in the Chinese population. LAMA1 SNPs may have a significant impact on the occurrence of esophageal cancer and may serve as potential diagnostic biomarkers.