Synthesis and cytotoxicity of novel (E)-2-phenylchroman-4-one-O-((1-substituted-1H-1, 2, 3-triazol-4-yl)methyl) oxime derivatives. Issue 12 (17th June 2020)

• Record Type: Journal Article
• Authors: Gutam, Madhu; Mokenapelli, Sudhakar; Yerrabelli, Jayaprakash Rao; Banerjee, Somesh; Roy, Partha; Chitneni, Prasad Rao
• Is Part Of: Synthetic communications. Volume 50:Issue 12(2020)
• Page Start: 1883
• Page End: 1891
• Publication Date: 2020-06-17
• Subjects: Cytotoxicity -- 13-dipolar cycloaddition -- flavanone -- 123-triazoles; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2020.1759645
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: A series of new flavanone-triazole hybrids (7a–m ) were synthesized from flavanone oximes (6a–c) via multistep synthetic strategy, involving Cu (I) catalyzed azide, alkyne 1, 3-dipolar cycloaddition by Click reaction. All the synthesized compounds were tested for their cytotoxicity against HCT-15, HeLa, NCI-H522, and HEK-293 (normal cell line) cell lines. Compounds 6a, 7a, 7b, 7d, 7e, 7j, and 7m showed the significant cytotoxicity, wherein compound 7b showed potential cytotoxicity against NCI-H522 cell line and compounds 6a and 7a were offensive with HEK-293 in their toxicity profile. Graphical Abstract: UF0001