Two Tumors, One Target: Preliminary Experience With 90Y-FAPI Therapy in a Patient With Metastasized Breast and Colorectal Cancer. (October 2021)

• Record Type: Journal Article
• Authors: Rathke, Hendrik; Fuxius, Stefan; Giesel, Frederik L.; Lindner, Thomas; Debus, Jürgen; Haberkorn, Uwe; Kratochwil, Clemens
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 10(2021)
• Publication Date: 2021-10
• Subjects: FAPI -- therapy -- breast cancer -- colorectal cancer -- theranostics; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003842
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: We report a patient with breast cancer (BC) diagnosed in 2009 with metachronous lymph node, liver, and bone metastases. In 2017, colorectal cancer with peritoneal metastases was additionally diagnosed and treated with 8 cycles of capecitabine due to its antitumor activity against both malignancies. At progression of both diseases, FAPI PET/CT demonstrated positive tumor targeting in BC-related metastases and colorectal cancer–related metastases. The patient received an experimental therapy with 90 Y-FAPI46. Although there was similar tracer uptake in the PET/CT, the radioligand therapy resulted in mixed response with disappearance of peritoneal metastases but minor efficacy treating the BC-related metastases.