Engineering precision therapies: lessons and motivations from the clinic. Issue 1 (24th November 2020)

• Record Type: Journal Article
• Authors: Xie, Mingqi; Viviani, Mirta; Fussenegger, Martin
• Is Part Of: Synthetic biology. Volume 6:Issue 1(2021)
• Publication Date: 2020-11-24
• Subjects: translational medicine -- synthetic biology -- cell-based therapies -- gene therapy -- ATMP; Synthetic biology -- Periodicals; 660.6
• DOI: 10.1093/synbio/ysaa024
• Languages: English
• ISSNs: 2397-7000

Abstract

Abstract: In the past decade, gene- and cell-based therapies have been at the forefront of the biomedical revolution. Synthetic biology, the engineering discipline of building sophisticated 'genetic software' to enable precise regulation of gene activities in living cells, has been a decisive success factor of these new therapies. Here, we discuss the core technologies and treatment strategies that have already gained approval for therapeutic applications in humans. We also review promising preclinical work that could either enhance the efficacy of existing treatment strategies or pave the way for new precision medicines to treat currently intractable human conditions.