Liquid biopsy: state of reproductive medicine and beyond. Issue 11 (25th September 2021)

• Record Type: Journal Article
• Authors: Schobers, Gaby; Koeck, Rebekka; Pellaers, Dominique; Stevens, Servi J C; Macville, Merryn V E; Paulussen, Aimée D C; Coonen, Edith; van den Wijngaard, Arthur; de Die-Smulders, Christine; de Wert, Guido; Brunner, Han G; Zamani Esteki, Masoud
• Is Part Of: Human reproduction. Volume 36:Issue 11(2021)
• Page Start: 2824
• Page End: 2839
• Publication Date: 2021-09-25
• Subjects: liquid biopsy -- circulating cells -- cell-free DNA -- ART -- IVF -- spent embryo culture medium -- non-invasive prenatal testing -- preimplantation genetic testing -- next generation sequencing -- artificial intelligence; Human reproduction -- Periodicals; 618
• DOI: 10.1093/humrep/deab206
• Languages: English
• ISSNs: 0268-1161

Abstract

ABSTRACT: Liquid biopsy is the process of sampling and analyzing body fluids, which enables non-invasive monitoring of complex biological systems in vivo . Liquid biopsy has myriad applications in health and disease as a wide variety of components, ranging from circulating cells to cell-free nucleic acid molecules, can be analyzed. Here, we review different components of liquid biopsy, survey state-of-the-art, non-invasive methods for detecting those components, demonstrate their clinical applications and discuss ethical considerations. Furthermore, we emphasize the importance of artificial intelligence in analyzing liquid biopsy data with the aim of developing ethically-responsible non-invasive technologies that can enhance individualized healthcare. While previous reviews have mainly focused on cancer, this review primarily highlights applications of liquid biopsy in reproductive medicine.