The efficacy of acupuncture for stable angina pectoris: A systematic review and meta-analysis. (18th September 2019)

• Record Type: Journal Article
• Authors: Yang, Mingxiao; Sun, Mingsheng; Du, Ting; Long, Hulin; Chen, Ji; Liang, Fanrong; Lao, Lixing
• Is Part Of: European journal of preventive cardiology. Volume 28:Number 13(2021)
• Page Start: 1415
• Page End: 1425
• Publication Date: 2019-09-18
• Subjects: Stable angina pectoris -- symptom management -- complementary and alternative medicine -- acupuncture -- patient-centered outcomes; Cardiovascular system -- Diseases -- Prevention -- Periodicals; Cardiac patients -- Rehabilitation -- Periodicals; 616.12
• DOI: 10.1177/2047487319876761
• Languages: English
• ISSNs: 2047-4873

Abstract

Abstract: Objective: The aim of this study was to assess the efficacy and safety of acupuncture in the treatment of patients with stable angina pectoris. Methods: A literature search was performed in nine databases, including PubMed and the Cochrane Library, from their inception to 30 August 2018. Randomized controlled trials that compared acupuncture therapy with sham acupuncture or no treatment were included. Two reviewers under the guidance of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines assessed the eligibility of each record and extracted essential information independently. The data were merged using a fixed-effect model. Results: Pooled analysis of 17 eligible trials with 1516 participants showed that acupuncture was associated with reduced angina attack frequency (–4.91; 95% confidence interval, –6.01– –3.82; p < 0.00001) and improved depression (–1.23; 95% confidence interval, –1.47– –1.00; p < 0.00001) and anxiety level (–0.96; 95% confidence interval, –1.16– –0.75; p < 0.00001) relative to sham treatment or standard care alone. No increased risk of adverse events was observed during treatment (relative risk, 0.70; 95% confidence interval, 0.33–1.48; p = 0.35). No significant improvement was shown in nitroglycerin use or angina intensity. The included studies were associated with unclear to high risk of selection or performance bias, and the quality of evidence was low to moderate. Conclusions: Acupuncture may safely and effectively improve physical restrictions, emotional distress, and attack frequency in patients with stable angina pectoris. However, angina intensity and medication use were not reduced. Studies with adequate blinding and a valid sham control group are still warranted due to the current low quality of evidence.