Enantioselective Synthesis of Axially Chiral Oxazole Biaryls by Copper‐Catalyzed Oxidation of Cyclic Diaryliodoniums. Issue 9 (1st March 2022)

• Record Type: Journal Article
• Authors: Zhu, Daqian; Sun, Yameng; Peng, Hui; Li, Hangni; Yan, Yang; Kuang, Haolin
• Is Part Of: European journal of organic chemistry. Volume 2022:Issue 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-01
• Subjects: Atropisomer -- Axial chirality -- Asymmetric catalysis -- Cylic diaryliodoniums -- Oxazole; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202101449
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: We report here a Cu‐catalyzed enantioselective intramolecular oxidation of cyclic diaryliodoniums. With readily available cyclic diaryliodoniums as building blocks, diversified axially chiral oxazole 2‐iodobiaryls were produced with excellent yield as well as excellent enantioselectivity. Furthermore, these chiral aryl iodides could be transformed into iodine (III) species in situ, which can be employed as chiral catalysts. Abstract : We report here a Cu‐catalyzed enantioselective intramolecular oxidation of cyclic diaryliodoniums. With readily available cyclic diaryliodoniums as building blocks, diversified axially chiral oxazole 2‐iodobiaryls were produced with excellent yield as well as excellent enantioselectivity.