Cover Feature: An Improved Protocol for the Morita‐Baylis‐Hillman Reaction Allows Unprecedented Broad Synthetic Scope (Eur. J. Org. Chem. 9/2022). Issue 9 (21st February 2022)

• Record Type: Journal Article
• Authors: Camilo, Nilton S.; Santos, Hugo; Zeoly, Lucas A.; Fernandes, Fábio S.; Rodrigues, Manoel T.; Silva, Thiago S.; Lima, Samia R.; Serafim, José Cláudio; de Oliveira, Aline S. B.; Carpanez, Arthur G.; Amarante, Giovanni W.; Coelho, Fernando
• Is Part Of: European journal of organic chemistry. Volume 2022:Issue 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-21
• Subjects: Brønsted acid -- C−C bond formation -- Morita-Baylis-Hillman -- Organocatalysis -- Sustainable chemistry; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202200183
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : The Cover Feature illustrates the effect of acetic acid on the rate of the Morita–Baylis–Hillman reaction. The use of acetic acid as a fuel (additive) increases the reaction rate in all tested cases, with special emphasis on electron‐rich electrophilic partners. We believe that a general acid catalysis mechanism is responsible for this increase in reaction rate. More information can be found in the Research Article by G. W. Amarante, F. Coelho et al .