Prostate-Specific Membrane Antigen PET Positivity in a Lung Mass: Diagnosis of Diffuse Large B-Cell Lymphoma. (February 2023)

• Record Type: Journal Article
• Authors: Caputo, Sydney A.; Jang, Albert; Talbert, Joshua; Saba, Nakhle S.; Sartor, Oliver
• Is Part Of: Clinical nuclear medicine. Volume 48:Number 2(2023)
• Page Start: 190
• Page End: 191
• Publication Date: 2023-02
• Subjects: 68Ga-PSMA PET/CT -- diffuse large B-cell lymphoma -- prostate carcinoma -- prostate-specific membrane antigen; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000004503
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract: An 84-year-old man with nonmetastatic castrate-sensitive prostate cancer was referred for a 68 Ga–prostate-specific membrane antigen (PSMA) PET/CT scan with a prostate-specific antigen level of 3.6 ng/mL for restaging. He was 22 years post–radical prostatectomy and had salvage radiation being managed with intermittent hormonal therapy. Imaging revealed a right lower lobe mass with increased PSMA uptake (SUVmax 6.2). Biopsy and subsequent immunostaining determined the mass to be diffuse large B-cell lymphoma. We report a case of diffuse large B-cell lymphoma diagnosed in the setting of PSMA positivity, highlighting awareness for oncologists and radiologists to know this possibility.