High perirenal fat thickness predicts a greater risk of recurrence in Chinese patients with unilateral nephrolithiasis. Issue 1 (31st December 2023)

• Record Type: Journal Article
• Authors: Huang, Haichao; Chen, Shi; Zhang, Wenzhao; Wang, Tao; Bai, Peide; Xing, Jinchun; Wang, Huiqiang; Chen, Bin
• Is Part Of: Renal failure. Volume 45:Issue 1(2023)
• Publication Date: 2023-12-31
• Subjects: Nephrolithiasis -- recurrence -- perirenal fat thickness -- obesity; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.1080/0886022X.2022.2158870
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: Introduction: The aim of this study was to evaluate the association between recurrence-free survival (RFS) and perirenal fat thickness (PFT) in a cohort of Chinese population with unilateral nephrolithiasis. Methods: We retrospectively reviewed the medical records of 81 patients with unilateral nephrolithiasis in our center from January 2019 to June 2019. PFT measured on computed tomography (CT) scans was evaluated. Kaplan-Meier curves and log-rank tests were used to assess significant differences in RSF between high-PFT and low-PFT groups within sexes. Univariable and multivariable Cox regression analyses were used to evaluate the potential risk factors for renal stone recurrence. Results: High PFT was significantly associated with high BMI and hyperlipidemia ( p = .003 and.047, respectively). The PFT of stone-bearing kidney was significantly greater than PFT of non-stone-bearing kidney (0.77 ± 0.60 cm vs. 0.67 ± 0.58 cm, p = .002) . During the follow-up periods (median 31 months), 21 (25.9%) patients experienced ipsilateral renal stone recurrence. In addition, Kaplan–Meier survival curves showed that patients with low PFT had a significant better RFS than those with high PFT ( p = .012). In the univariable Cox analyses, male sex and high PFT were significantly associated with a poor RFS ( p = .042 and .018, respectively). Moreover, both male sex and high PFT retained significance in the multivariable analyses ( p = .045 and .020, respectively). Conclusions: Our findings suggested that PFT is a noninvasive and feasible parameter, which may help in the risk stratification of renal stone recurrence in the follow-up periods.