Towards fully automated deep-learning-based brain tumor segmentation: Is brain extraction still necessary?. (April 2023)

• Record Type: Journal Article
• Authors: Pacheco, Bruno Machado; Cassia, Guilherme de Souza e; Silva, Danilo
• Is Part Of: Biomedical signal processing and control. Volume 82(2023)
• Publication Date: 2023-04
• Subjects: Brain extraction -- Skull-stripping -- Brain tumor segmentation -- Deep learning -- Evaluation -- TCGA; Signal processing -- Periodicals; Biomedical engineering -- Periodicals; Signal Processing, Computer-Assisted -- Periodicals; Image Processing, Computer-Assisted -- Periodicals; Biomedical Engineering -- Periodicals; 610.28
• DOI: 10.1016/j.bspc.2022.104514
• Languages: English
• ISSNs: 1746-8094

Abstract

Abstract: State-of-the-art brain tumor segmentation is based on deep learning models applied to multi-modal MRIs. Currently, these models are trained on images after a preprocessing stage that involves registration, interpolation, brain extraction (BE, also known as skull-stripping) and manual correction by an expert. However, for clinical practice, this last step is tedious and time-consuming and, therefore, not always feasible, resulting in skull-stripping faults that can negatively impact the tumor segmentation quality. Still, the extent of this impact has never been measured for any of the many different BE methods available. In this work, we propose an automatic brain tumor segmentation pipeline and evaluate its performance with multiple BE methods. Our experiments show that the choice of a BE method can compromise up to 15.7% of the tumor segmentation performance. Moreover, we propose training and testing tumor segmentation models on non-skull-stripped images, effectively discarding the BE step from the pipeline. Our results show that this approach leads to a competitive performance at a fraction of the time. We conclude that, in contrast to the current paradigm, training tumor segmentation models on non-skull-stripped images can be the best option when high performance in clinical practice is desired. Highlights: State-of-the-art brain tumor segmentation models require expert brain segmentation. Automatic brain extraction can compromise 15.7% of the tumor segmentation performance. Single-stage tumor segmentation on raw images may outperform state-of-the-art models.