A case of multiple myeloma diagnosed by extramedullary disease in the submandibular region. Issue 3 (May 2023)

• Record Type: Journal Article
• Authors: Koizumi, Koichi; Sakaue, Taishi; Nakase, Youji; Obayashi, Fumitaka; Ando, Toshinori; Shintani, Tomoaki; Yanamoto, Souichi
• Is Part Of: Journal of oral and maxillofacial surgery, medicine, and pathology. Volume 35:Issue 3(2023)
• Page Start: 247
• Page End: 250
• Publication Date: 2023-05
• Subjects: Multiple myeloma -- Extramedullary disease -- Submandibular region; Mouth -- Surgery -- Periodicals; Face -- Surgery -- Periodicals; Maxilla -- Surgery -- Periodicals; Oral medicine -- Periodicals; Mouth -- Diseases -- Pathogenesis -- Periodicals; Surgery, Oral -- Periodicals; Oral Medicine -- Periodicals; Pathology, Oral -- Periodicals; Face -- Surgery; Maxilla -- Surgery; Mouth -- Diseases -- Pathogenesis; Mouth -- Surgery; Oral medicine; Electronic journals -- Sciences; Electronic journals -- Medicine; Periodicals; 617.522059
• DOI: 10.1016/j.ajoms.2022.10.006
• Languages: English
• ISSNs: 2212-5566

Abstract

Abstract: Multiple myeloma is a hematologic malignancy characterized by neoplastic proliferation of monoclonal plasma cells. The mass formed within the soft tissue is particularly called extramedullary disease in multiple myeloma. This disease rarely occurs in the head and neck regions. Notably, submandibular extramedullary lesions have not been reported. Therefore, we report a case of multiple myeloma diagnosed with extramedullary disease in the submandibular region. A 70-year-old woman was referred to our clinic due to painless swelling on the left side of the submandibular region. We confirmed the presence of a relatively well-circumscribed subglobular tumor on the left side of the submandibular region on contrast-enhanced computed tomography and magnetic resonance imaging. The tumor was resected surgically, including the circumferential tissue, with the patient under general anesthesia. The tumor was histologically diagnosed as a plasma cell neoplasm. Positron emission tomography-computed tomography showed an osteolytic lesion in the sacral region. A bone marrow examination diagnosed multiple myeloma of IgG-λ-type, ISS Ⅱ stage. The patient has been receiving continuous chemotherapy for multiple myeloma for 1 year after operation and has no recurrence in the submandibular region. Data Availability Statement: The data presented in this study are available on request from the corresponding author. Publicly available datasets were analyzed in this study.