Reactive oxygen species responsive magnetic polylactic co-glycolic acid microspheres: In vitro drug release studies. (March 2023)

• Record Type: Journal Article
• Authors: Renukadevi, Cinna Raj; Ayyanaar, Srinivasan; Kesavan, Mookkandi Palsamy; Umamaheswari, Chidambaram; Thenmozhi, Ramasamy; Jayanthipriya, Kalimuthu; Ramapriya, Chandramouli; Bhaskar, R.; Kandasamy, Kumar
• Is Part Of: Materials today communications. Volume 34(2023)
• Publication Date: 2023-03
• Subjects: Magnetic iron oxide nanoparticles -- 5-fluorouracil -- Poly(D, L-lactide-co-glycolic acid) -- ROS responsive -- Targeted drug delivery; Materials science -- Periodicals; 620.11
• DOI: 10.1016/j.mtcomm.2023.105474
• Languages: English
• ISSNs: 2352-4928

Abstract

Abstract: Over the last few decades, nanotheranostic therapies with reactive oxygen species (ROS)-responsive qualities have gotten a lot of interest, because ROS is linked to some of the most serious pathological illnesses, such as cancer, inflammatory diseases, infection, and so on. When activated inflammatory cells are exposed to oxidative stress and pH levels below 7, they create free radicals. We report, the antioxidant drug 5-fluorouracil (5-FU) encapsulated polylactic co-glycolic acid (PLGA) magnetic microsphere (Fe3 O4 @OA-5-FU-PLGA-MMS) system in this study, which results in an oleic acid (OA) incorporated ROS-responsive therapeutic system with potent cytotoxic properties. The targeted release of payload 5-FU from Fe3 O4 @ OA-5-FU-PLGA-MMS is induced by ROS such as H2 O2 in acidic pH at 5.2 (87.20%) and in basic pH at 7.4 (78.40%). The result shows the malignant cells targeting efficacy of the Fe3 O4 @OA-5-FU-PLGA-MMS and implying that this system might be used as effective drug carrier in cancer theranostics. Graphical Abstract: ga1 Highlights: 5-FU encapsulated magnetic microspheres were synthesized via W1/O/W2 emulsification method. The targeted 5-FU release efficacy of magnetic microspheres were evaluated in the presence of ROS. The magnetic microspheres showed 87.20% of in vitro drug releasing efficiency in cancer site environment.