A pilot study of same-day MRI-only simulation and treatment with MR-guided adaptive palliative radiotherapy (MAP-RT). (March 2023)

• Record Type: Journal Article
• Authors: Schiff, Joshua P.; Maraghechi, Borna; Chin, Re-I.; Price, Alex; Laugeman, Eric; Rudra, Souman; Hatscher, Casey; Spraker, Matthew B.; Badiyan, Shahed N.; Henke, Lauren E.; Green, Olga; Kim, Hyun
• Is Part Of: Clinical and translational radiation oncology. Volume 39(2023)
• Publication Date: 2023-03
• Subjects: Physics -- MRI -- Adaptive radiation -- Palliative radiation -- Electron density calculations -- Treatment -- CT Simulation-Free; Cancer -- Radiotherapy -- Periodicals; Oncology -- Periodicals; Cancer -- Radiotherapy; Oncology; Radiation Oncology; Neoplasms -- radiotherapy; Translational Medical Research; Periodicals; Electronic journals; Periodicals; 616.9940642
• DOI: 10.1016/j.ctro.2022.100561
• Languages: English
• ISSNs: 2405-6308

Abstract

Highlights: A pilot study of MRI-only simulation and treatment with palliative radiation. Simulation and first fraction were performed on the same day. Electron densities were derived using bulk density override method. 99% of fractions were completed at first on-table attempt. No grades 3 through 5 toxicities were recorded. Abstract: We conducted a prospective pilot study evaluating the feasibility of same day MRI-only simulation and treatment with MRI-guided adaptive palliative radiotherapy (MAP-RT) for urgent palliative indications (NCT#03824366). All (16/16) patients were able to complete 99% of their first on-table attempted fractions, and no grades 3–5 toxicities occurred.