Prognostic significance of natural products against multidrug tumor resistance. (31st March 2023)

• Record Type: Journal Article
• Authors: Garg, Pankaj; Garg, Rachana; Horne, David; Awasthi, Sanjay; Salgia, Ravi; Singhal, Sharad S.
• Is Part Of: Cancer letters. Volume 557(2023)
• Publication Date: 2023-03-31
• Subjects: Chemoprevention -- Natural products -- Chemotherapeutic drugs -- Drug resistance; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2023.216079
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Cancer is a pervasive, constantly evolving, and significant public health concern. The number of new cancer cases has risen dramatically in the last decades, making it one of the top causes of poor health and mortality worldwide. Although various treatment strategies, including surgery, radiation, and pharmaceutical therapies, have evolved into more sophisticated, precise methods, there is not much improvement in the cancer-related death toll. Consequently, natural product-based therapeutic discoveries have recently been considered an alternative approach. According to an estimate, one-third of the top twenty medications in today's market have a natural plant-product-based origin. Accordingly, primary prevention is an essential component of worldwide cancer control. This review provides an overview of the mechanisms of action of bioactive ingredients in natural dietary products that may contribute to the prevention and management of multiple malignancies. Highlights: Natural products prevent drug resistance in cancer chemotherapy. Dietary natural products decrease tumor initiation, proliferation, invasion, and promote normal differentiation. Dietary natural products inhibit tumor metastasis. Phytoconstituents block tumor-promoting PI3K/Akt/mTOR/MAPK pathway