Left ventricular systolic dysfunction during acute pulmonary embolism. Issue 223 (March 2023)

• Record Type: Journal Article
• Authors: Cires-Drouet, Rafael; LaRocco, Allison; Soldin, Danielle; John, Thomas; Toursavadkohi, Shahab; Nagarsheth, Khanjan; Dahi, Siamak; Marsella, Justin; Mayorga-Carlin, Minerva; Sorkin, John D.; Jones, Kevin; Haase, Daniel; Hong, Susie N.; Lal, Brajesh K.; Griffith, Bartley; Ramani, Gautam; Taylor, Bradley
• Is Part Of: Thrombosis research. Issue 223(2023)
• Page Start: 1
• Page End: 6
• Publication Date: 2023-03
• Subjects: Pulmonary embolism -- Left ventricle dysfunction -- Low EF; Thrombosis -- Periodicals; 616.135
• DOI: 10.1016/j.thromres.2023.01.011
• Languages: English
• ISSNs: 0049-3848

Abstract

Abstract: Background: Heart failure increases the risk of death in acute pulmonary embolism (PE). The role of the left ventricle (LV) in acute PE is not well defined. Objective: To identify the prevalence of LV systolic dysfunction, morphology, and prognosis of the LV during an acute PE. Methods: Retrospective study (26-months) of patients diagnosed with an acute PE presenting with LV systolic dysfunction at the University of Maryland. Results: Among 769 acute PE patients, 78 (10.5 %) had LV systolic dysfunction and 42 (53.8 %) had history of cardiac disease. Patients without history of cardiac disease were younger (mean age [SD] 54.9 [16.8] vs. 62.6 [16.6]; p = 0.04), had a higher BMI (31.2 [12.2] vs. 29.2 [7.7]; p = 0.005), and less hypertension (20 [34.5 %] vs. 38 [65.5 %]; p = 0.0005). A massive PE was most common in patients without history of cardiac disease (8[22.2 %] vs. 2[4.7 %], p = 0.02). There was no difference in clot burden, but right ventricular strain was more frequently seen in patients without history cardiac disease in the initial CT (p = 0.001). The median troponin and lactate were similar in both groups. In 41 patients with follow-up echocardiograms, improvement in LVEF% was observed in patients without cardiac history (median Δ LVEF% [IQR]; 20 [6.2–25.0]). While patients with cardiac disease did not demonstrate similar changes (median Δ LVEF% [IQR]; 0 [−5–17.5]; p = 0.01). In hospital mortality was 12.8 % with no difference between both groups (p = 0.17). Conclusion: Pulmonary embolism can be associated with LV systolic dysfunction, even in patients without history of cardiac disease.