The Role of Extra-motor Networks in Upper Limb Motor Performance Post-stroke. (15th March 2023)

• Record Type: Journal Article
• Authors: Mattos, Daniela J.S.; Rutlin, Jerrel; Hong, Xin; Zinn, Kristina; Shimony, Joshua S.; Carter, Alexandre R.
• Is Part Of: Neuroscience. Volume 514(2023)
• Page Start: 1
• Page End: 13
• Publication Date: 2023-03-15
• Subjects: cerebrovascular accident -- upper limb function -- neurological rehabilitation -- magnetic resonance imaging -- functional connectivity -- task-specific training; ARAT action research arm test -- BOLD blood oxygenation level-dependent -- CL contralesional hemisphere -- CON cingulo-opercular network -- DAN dorsal attention network -- DMN default mode network -- fMRI functional magnetic resonance imaging -- FPN fronto-parietal network -- IL ipsilesional -- ROI region of interest -- rsFC resting-state functional connectivity -- SAL salience network -- SMN sensorimotor network; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2023.01.033
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: We investigated how extra-motor networks support motor function post-treatment in stroke. Networks other than sensorimotor networks were associated with motor improvements. Baseline cingulo-opercular connectivity predicted motor improvements. Changes in salience connectivity were associated with the amount of current motor gain. Cognitive networks may contribute to motor gains post-treatment in chronic stroke. Abstract: Background: Motor improvement post-stroke may happen even if resting state functional connectivity between the ipsilesional and contralesional components of the sensorimotor network is not fully recovered. Therefore, we investigated which extra-motor networks might support upper limb motor gains in response to treatment post-stroke. Methods : Both resting state functional connectivity and upper limb capacity were measured prior to and after an 8-week intervention of task-specific training in 29 human participants [59.24 ± (SD) 10.40 yrs., 12 females and 17 males] with chronic stroke. The sensorimotor and five extra-motor networks were defined: default mode, frontoparietal, cingulo-opercular, dorsal attention network, and salience networks. The Network Level Analysis toolbox was used to identify network pairs whose connectivities were enriched in connectome-behavior relationships. Results: Mean upper limb capacity score increased 5.45 ± (SD) 5.55 following treatment. Baseline connectivity of some motor but mostly extra-motor network interactions of cingulo-opercular and default-mode networks were predictive of upper limb capacity following treatment. Also, changes in connectivity for extra-motor interactions of salience with default mode, cingulo-opercular, and dorsal attention networks were correlated with gains in upper limb capacity. Conclusions : These connectome-behavior patterns suggest larger involvement of cingulo-opercular networks in prediction of treatment response and of salience networks in maintenance of improved skilled behavior. These results support our hypothesis that cognitive networks may contribute to recovery of motor performance after stroke and provide additional insights into the neural correlates of intensive training.