Prevalence and risk factors of bovine tuberculosis in slaughtered cattle, Malawi. Issue 2 (February 2023)

• Record Type: Journal Article
• Authors: Kapalamula, Thoko Flav; Kawonga, Francis; Shawa, Misheck; Chizimu, Joseph; Thapa, Jeewan; Nyenje, Mirriam Ethel; Mkakosya, Rajhab Sawasawa; Hayashida, Kyoko; Gordon, Stephen; Nakajima, Chie; Munyeme, Musso; Hang'ombe, Bernard M.; Suzuki, Yasuhiko
• Is Part Of: Heliyon. Volume 9:Issue 2(2023)
• Publication Date: 2023-02
• Subjects: Bovine tuberculosis -- Slaughtered cattle -- Malawi -- Regional abattoirs -- Mycobacterium bovis; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2023.e13647
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: Bovine tuberculosis (bTB) is an infectious disease with significant socioeconomic, animal, and public health impacts. However, the prevalence of bTB remains largely unclear in Malawi due to a paucity of information. Additionally, the existence of multiple risk factors is postulated to enhance bTB transmission in animals. A cross-sectional survey to estimate the prevalence of bTB, animal characteristics and identify associated risk factors was conducted from slaughtered cattle at three major regional abattoirs (southern, central and northern regions) in Malawi. Out of a total of 1547 cattle examined, 154 (9.95%) had bTB-like lesions in various visceral organs and lymph nodes; one sample per animal was collected, processed, and cultured in the in the BACTEC Mycobacterial growth indicator tube (MGIT) 960 system. From the 154 cattle that showed tuberculous like lesions, only 112 were positive on MGIT and 87 were confirmed to have M. bovis based on multiplex PCR. Cattle from the southern region (odds ratio (OR) = 1.96, 95% CI: 1.03–3.85) and central region (OR = 2.00, 95% CI: 1.16–3.56) were more likely presented with bTB-like lesions at slaughter than from the northern region. The risk of having bTB-like lesions was higher in females (OR = 1.51, CI: 1.00–2.29), older cattle (OR = 2.17, CI: 1.34–3.37), and crossbreeds (OR = 1.67, 95% CI: 1.12–2.47) than in males, younger animals, and Malawi Zebu breed, respectively. The high prevalence of bTB is of critical concern and necessitates active surveillance and strengthening of the current control strategies under a One Health (OH) approach at the animal-human interface. Highlights: The prevalence of bovine tuberculosis (bTB) in slaughtered cattle at regional abattoirs in Malawi was assessed for the first time. Out of 1547 cattle slaughtered and examined, 154 (9.95%) had granulomatous bTB-like lesions. The risk of an animal having bTB was associated with age and breed. Based on these findings, there is need to enhance current control strategies and active surveillance of bTB.