Efficacy and safety of lobeglitazone, a new Thiazolidinedione, as compared to the standard of care in type 2 diabetes mellitus: A systematic review and meta-analysis. Issue 1 (January 2023)

• Record Type: Journal Article
• Authors: Joshi, Shashank R.; Das, Saibal; Xaviar, Suja; Samajdar, Shambo Samrat; Saha, Indranil; Sarkar, Sougata; Mukherjee, Shatavisa; Tripathi, Santanu Kumar; Pal, Jyotirmoy; Chatterjee, Nandini
• Is Part Of: Diabetes & metabolic syndrome. Volume 17:Issue 1(2023)
• Publication Date: 2023-01
• Subjects: Blood glucose -- Glycated hemoglobin (HbA1C) -- Lipid profile -- Lobeglitazone -- Thiazolidinedione; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2022.102703
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Aim: This systematic review and meta-analysis was conducted to evaluate the efficacy and safety of lobeglitazone as compared to the standard of care (SOC) in patients with type 2 diabetes mellitus (T2DM). Methods: Databases were searched for relevant randomized controlled trials. The primary outcome was the comparison of the glycated hemoglobin (HbA1C) level after 24 weeks. Pooled mean differences and odds ratios were calculated using random-effects models. Results: Of 267 studies that were screened, four were included. Treatment with adjunct lobeglitazone showed a reduction in the HbA1C level [mean difference: −0.23% (95% CI: −0.62 to 0.16); p = 0.24; i 2 : 87%; moderate GRADE (Grading of Recommendations Assessment, Development and. Evaluation) of evidence], fasting blood glucose level [mean difference: −7.12 mg/dl (95% CI: −20.09 to 5.85); p = 0.28; i 2 : 87%; moderate GRADE of evidence], and lipid profile as compared to those following treatment with the SOC; however, the changes were not statistically significant. The risk of hypoglycemia was significantly lower [odds ratio: 0.24 (95% CI: 0.08 to 0.70); p < 0.05; i 2 : 0%; moderate GRADE of evidence] without any significant difference in the risk of drug-related adverse events [odds ratio: 1.59 (95% CI: 0.87 to 2.93); p = 0.13; i 2 : 0%; moderate GRADE of evidence] following treatment with lobeglitazone as compared to those following treatment with the SOC. Conclusion: Treatment with adjunct lobeglitazone showed changes in the blood glycemic status and lipid profile similar to SOC in patients with T2DM, and the results were not statistically significant. Lobeglitazone was well tolerated; its safety profile was comparable to SOC. Highlights: Adjunct lobeglitazone showed improvements in the blood glycemic status and lipid profile. The results were; however, not statistically significant. The safety profile of lobeglitazone was good in patients with type 2 diabetes mellitus.