Association of comorbid depression and obesity with cardiometabolic multimorbidity among middle-aged and older Chinese adults: A cohort study. (April 2023)

• Record Type: Journal Article
• Authors: Qin, Kang; Bai, Shigen; Chen, Weiqing; Li, Jinghua; Guo, Vivian Yawei
• Is Part Of: Archives of gerontology and geriatrics. Volume 107(2023)
• Publication Date: 2023-04
• Subjects: Epidemiology -- Comorbidity -- Depressed mood -- Excess weight -- Cardiometabolic diseases -- China; Aging -- Periodicals; Geriatrics -- Periodicals; Gerontology -- Periodicals; Electronic journals; 305.26
• DOI: 10.1016/j.archger.2022.104912
• Languages: English
• ISSNs: 0167-4943

Abstract

Highlights: The impact of comorbid depression and obesity on the risk of cardiometabolic multimorbidity was assessed in a cohort study. Participants with both depression and obesity had the highest risk of incident cardiometabolic multimorbidity. Interventions targeting at this high-risk group may be beneficial to reduce the burden of cardiometabolic multimorbidity. Abstract: Purpose: To evaluate the association of comorbid depression and obesity with the risk of incident cardiometabolic multimorbidity among middle-aged and older Chinese adults. Methods: This cohort study extracted data from the 2011 and 2015 waves of the China Health and Retirement Longitudinal Study (CHARLS). Depression was confirmed by the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) with a cut-off score ≥10. Obesity was defined as a body mass index ≥28 kg/m 2 . Participants were categorized into four groups based on depression and obesity status at baseline, i.e., with neither condition, depression only, obesity only, and with both conditions. Cardiometabolic multimorbidity was defined as the coexistence of two or more of heart diseases, stroke, and diabetes mellitus. Logistic regression models were established to estimate the associations. Results: A total of 9, 308 participants without cardiometabolic multimorbidity at baseline were included (mean [SD] age, 58.8 [9.0] years; 4, 449 [47.8%] were males). During four-year of follow-up, 349 (3.8%) participants developed cardiometabolic multimorbidity. Compared to participants without depression or obesity, comorbid depression and obesity was associated with greater risk of cardiometabolic multimorbidity (adjusted OR: 4.79, 95% CI: 3.09–7.43) than that in participants with depression alone (adjusted OR: 1.84, 95% CI: 1.37–2.46) or obesity alone (adjusted OR: 2.26, 95% CI: 1.48–3.45). The findings were consistent in different gender and age groups. Conclusions: Comorbid depression and obesity was associated with excessive risk of cardiometabolic multimorbidity. Intervention targeting at individuals with both depression and obesity might have substantial benefit in minimizing the risk of cardiometabolic multimorbidity.