Hormesis-tempting stressors driven by evolutionary factors for mitigating negative impacts instigated over extended exposure to chemical elements. (1st April 2023)

• Record Type: Journal Article
• Authors: Sun, Xinwei; Anoopkumar, A.N.; Aneesh, Embalil Mathachan; Madhavan, Aravind; Binod, Parameswaran; Kuddus, Mohammed; Pandey, Ashok; Sindhu, Raveendran; Awasthi, Mukesh Kumar
• Is Part Of: Environmental pollution. Volume 322(2023)
• Publication Date: 2023-04-01
• Subjects: Compounds -- Stress -- Environment -- Gene -- Free radical; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2023.121246
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: The adaptive responses to moderate environmental challenges by the biological systems have usually been credited to hormesis. Since the hormetic biphasic dose-response illustrates a prominent pattern towards biological responsiveness, the studies concerning such aspects will get much more significance in risk assessment practices and toxicological evaluation research. From this point of view, the past few epochs have witnessed the extending recognition of the notion concerning hormesis. The extraction of its basic foundations of evolutionary perspectives-along with the probable underlying molecular and cellular mechanisms followed by the practical implications to enhance the quality of life. To get better and more effective output in this regard, the present article has evaluated the various observations of previous investigations. The intent of integrating the novel inferences concerning the hormesis-tempting stressors driven by predominant evolutionary factors for mitigating the adverse impacts that were prompted over frequent and continuous exposure to the various chemical elements. Such inferences can offer extensive insight into the implications concerning the risk assessment of hormesis. Graphical abstract: Image 1 Highlights: Prevalent exposure to the chemicals prominently instigates complications were illustrated. Molecular mechanisms of the stress response need to be unveiled. Trial-and-error strategy for hormesis-tempting stressors were discussed. Homeodynamics can be recognized as a hopeful holistic strategy.