Surgical site infection prevention in abdominal surgery: is intraoperative wound irrigation with antiseptics effective? Protocol for a systematic review and meta-analysis. Issue 2 (14th February 2023)

• Record Type: Journal Article
• Authors: Mueller, Tara; Dimpel, Rebekka; Kehl, Victoria; Friess, Helmut; Reim, Daniel
• Is Part Of: BMJ open. Volume 13:Issue 2(2023)
• Publication Date: 2023-02-14
• Subjects: WOUND MANAGEMENT -- Pancreatic surgery -- Hepatobiliary surgery -- Colorectal surgery -- Adult surgery; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2022-066140
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: Surgical site infection (SSI) after laparotomy still represents the most frequent postoperative complicationin abdominal surgery. The effectiveness of reducing SSI rates by intra-operative irrigation of the incisional wound with antiseptic solutions or saline has been much debated, and recommendations on its use are divergent. Therefore, we aim to conduct a systematic review and meta-analysis, focusing specifically on procedures by laparotomy and considering recent evidence only. Methods and analysis: The systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) statement. On 1 July 2022, PubMed/MEDLINE, Cochrane, Central Register of Controlled Trials and EMBASE were searched for the following predefined terms: (Surgical site infection) AND ((irrigation) OR (wound irrigation) OR (lavage)) AND ((abdominal surgery) OR (laparotomy). The search was limited to peer-revied publications, dating after 1 January 2000 in English or German language. Systematic reviews and meta-analyses were included for reference screening. Case reports, case series, non-systematic reviews and studies without follow-up information were excluded. The primary outcome is the rate of postoperative SSI after abdominal surgery by laparotomy. Meta-analysis is pooled using the Mantel-Haenszel method for random effects. The risk of bias in randomised studies will be assessed using the Cochrane developed RoB 2-tool, and the ROBINS-I tool for non-randomised studies. Completion of the analysis and publication is planned in March 2023. Ethics and dissemination: Ethical approval is not necessary for this study, as no new data will be collected. The results of the final study will be published in a peer-reviewed open-access journal. PROSPERO registration number: CRD42022321458.