Mechanosynthesis of Triazolyl‐bis(indolyl)methane Pharmacophores via Gold Catalysis: A Prelude to Their Molecular Electronic Properties and Biological Potency. (16th January 2023)

• Record Type: Journal Article
• Authors: Sundaramoorthy, Ramachandran; Vadivelu, Murugan; Karthikeyan, Kesavan; Praveen, Chandrasekar
• Is Part Of: ChemMedChem. Volume 18:Number 4(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-16
• Subjects: triazolyl-bis(indolyl)methanes -- mechanosynthesis -- π-orbital properties -- biological screening -- molecular docking; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.202200529
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract: Chemical structures possessing both 1, 2, 3‐triazole and bis (indolyl)methane fragments gained considerable interest in drug synthesis owing to their established biological efficacies. However, 1, 2, 3‐triazoles linked at the bridging position of bis (indolyl)methane is a logical and unexplored design approach. In this regard, nine new triazolyl‐ bis (indolyl)methane conjugates under AuCl catalyzed ball‐milling conditions were accomplished. Comparative evaluation on absorptive and emissive properties of the synthesized dyads were also analyzed. To unravel the influence of different peripheral substituents on the electronic structure and π‐orbital properties, theoretical investigations were performed. Screening of molecules for free radical scavenging, anti‐inflammatory and antidiabetic showed comparable potency against reference drugs. In particular, compounds 7 h, 7 d and 7 a displayed good efficiency of α‐amylase inhibition. The DNA gyrase inhibitory potential of all compounds were assessed in silico which revealed high binding affinity (ΔG=−8.99 Kcal/mol) for 7 i followed by 7 h (ΔG=−7.80 Kcal/mol) with the targeted protein. Abstract : Triazolyl‐ bis (indolyl)methane conjugates were synthesized using mechanochemical gold catalysis as key step. Features like structural, photophysical, orbital along with quantum chemical parameters of the synthesized conjugates were analysed. Screening for antioxidant, anti‐inflammatory and antidiabetic activities revealed comparable efficacies with standard drugs. High potencies towards α‐amylase inhibition were assessed by molecular docking.