Switchable ROS Scavenger/Generator for MRI‐Guided Anti‐Inflammation and Anti‐Tumor Therapy with Enhanced Therapeutic Efficacy and Reduced Side Effects. Issue 5 (24th November 2022)

• Record Type: Journal Article
• Authors: Li, Muyao; Huo, Linlin; Zeng, Jie; Zhu, Guifen; Liu, Xiangqing; Zhu, Xianglong; Huang, Guoming; Wang, Yi; Ni, Kaiyuan; Zhao, Zhenghuan
• Is Part Of: Advanced healthcare materials. Volume 12:Issue 5(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-24
• Subjects: activable MRI -- low side effects -- microenvironments -- photodynamic therapy -- switchable ROS scavenger/generators; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202202043
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Photosensitizer in photodynamic therapy (PDT) accumulates in both tumor and adjacent normal tissue due to low selective biodistribution, results in undesirable side effect with limited clinic application. Herein, an intelligent nanoplatform is reported that selectively acts as reactive oxygen species (ROS) scavenger in normal tissue but as ROS generator in tumor microenvironment (TME) to differentially control ROS level in tumor and surrounding normal tissue during PDT. By down‐regulating the produced ROS with dampened cytokine wave in normal tissue after PDT, the nanoplatform reduces the inflammatory response of normal tissue in PDT, minimizing the side effect and tumor metastasis in PDT. Alternatively, the nanoplatform switches from ROS scavenger to generator through the glutathione (GSH) responsive degradation in TME, which effectively improves the PDT efficacy with reduced GSH level and amplified oxidative stress in tumor. Simultaneously, the released Mn ions provide real‐time and in situ signal change of magnetic resonance imaging (MRI) to monitor the reversal process of catalysis activity and achieve accurate tumor diagnosis. This TME‐responsive ROS scavenger/generator with activable MRI contrast may provide a new dimension for design of next‐generation PDT agents with precise diagnosis, high therapeutic efficacy, and low side effect. Abstract : Switchable system that increases reactive oxygen species (ROS) level in tumor while reducing ROS in normal tissue is desirable for ROS based therapy. This study develops an intelligent nanoplatform that selectively act as ROS scavenger in normal tissue but as ROS generator in tumor with activable magnetic resonance imaging to treat tumor with high efficacy and low side effect.