A phase II study of antiangiogenic therapy (Apatinib) plus chemotherapy as second‐line treatment in advanced small cell lung cancer. (9th September 2022)

• Record Type: Journal Article
• Authors: Xu, Yinghui; Wang, Xu; Sun, Chao; Gao, Zhiru; He, Hua; Qiu, Shi; Guo, Ye; Ma, Xiaohui; Song, Junya; Ma, Kewei
• Is Part Of: Cancer medicine. Volume 12:Number 3(2023)
• Page Start: 2979
• Page End: 2989
• Publication Date: 2022-09-09
• Subjects: angiogenesis -- apatinib -- small cell lung cancer (SCLC) -- targeted therapy -- VEGFR2; 616.994005
• DOI: 10.1002/cam4.5217
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Introduction: Currently, only a few options are available for the treatment of patients with small‐cell lung cancer (SCLC) after the failure of first‐line platinum‐based chemotherapy. The present study aimed to evaluate the efficacy and safety of apatinib plus chemotherapy for second‐line treatment of advanced SCLC. Patients and Methods: This prospective clinical trial recruited patients treated with apatinib plus second‐line chemotherapy until disease progression or intolerable toxicity. Logrank test power analysis was used for calculating samples. The primary endpoint was progression‐free survival (PFS), and the secondary endpoints were objective response rate (ORR), disease control rate (DCR), overall survival (OS), and safety. Results: A total of 29/31 enrolled patients were available for response evaluation until October 2019. The ORR and DCR were 27.59% (8/29) and 96.55% (28/29), respectively. The median PFS and OS were 7.36 months and 14.16 months, respectively, indicating better efficacy compared with the standard second‐line chemotherapies. The most common adverse events (AEs) were neutropenia (41.94%, 13/31), followed by leucopenia (35.48%, 11/31) and thrombocytopenia (25.81%, 8/31). The grade 3–4 AEs occurred in 12 (38.71%) patients, of which neutropenia (19.35%, 6/31), leucopenia (9.68%, 3/31), and proteinuria (6.45%, 2/31) were most common. Patients receiving an initial dose of apatinib 250 mg had a better tolerance. Conclusion: Antiangiogenic therapy plus chemotherapy had encouraging efficacy in advanced SCLC patients, which provides an insight into the current status of second‐line therapy in SCLC. Abstract : Antiangiogenic therapy (Apatinib) plus chemotherapy had better efficacy compared with standard second‐line chemotherapies for advanced SCLC patients. No more intolerable toxicities were observed for this new regimen, which should provide a highlight view on the current status of second‐line therapy in SCLC.