Comprehensive review of the use of hydrogel spacers prior to radiation therapy for prostate cancer. (24th June 2022)

• Record Type: Journal Article
• Authors: Harvey, Michael; Ong, Wee Loon; Chao, Michael; Udovicich, Cristian; McBride, Sean; Bolton, Damien; Eastham, James; Perera, Marlon
• Is Part Of: BJU international. Volume 131:Number 3(2023)
• Page Start: 280
• Page End: 287
• Publication Date: 2022-06-24
• Subjects: hydrogel -- hydrogel spacer -- prostate cancer -- radiotherapy -- rectal toxicity; Genitourinary organs -- Diseases -- Periodicals; Genitourinary organs -- Surgery -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1111/bju.15821
• Languages: English
• ISSNs: 1464-4096

Abstract

Abstract : Objectives: To provide a comprehensive narrative review of the published data on the impact of hydrogel spacers on rectal dosimetry and toxicity and to outline the practicalities of inserting hydrogel spacers. Results: A growing body of evidence suggests that the administration of hydrogel spacers is safe and is associated with limited peri‐operative morbidity. The impact on rectal dosimetry has been clearly established and use of hydrogel spacers is associated with reduced rectal morbidity. These results have been corroborated by several Phase II and III clinical trials and subsequent meta‐analysis. There are several areas for future research, including the role of hydrogel spacers in prostate stereotactic beam radiotherapy and post‐radiotherapy local recurrence. Conclusions: Hydrogel spacers provide a low‐morbidity method to potential reduce rectal toxicity after radiation therapy in men with prostate cancer. Data outlining sexual function and oncological outcomes are limited to date. Future studies, currently being conducted, may provide further clarification of the role of hydrogel spacers in prostate cancer management.