Heart development and regeneration—a multi‐organ effort. (18th December 2021)

• Record Type: Journal Article
• Authors: Filosa, Alessandro; Sawamiphak, Suphansa
• Is Part Of: FEBS journal. Volume 290:Number 4(2023)
• Page Start: 913
• Page End: 930
• Publication Date: 2021-12-18
• Subjects: development -- gut -- heart -- immune system -- inter‐organ interactions -- microbiota -- nervous system -- regeneration; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.16319
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : Development of the heart, from early morphogenesis to functional maturation, as well as maintenance of its homeostasis are tasks requiring collaborative efforts of cardiac tissue and different extra‐cardiac organ systems. The brain, lymphoid organs, and gut are among the interaction partners that can communicate with the heart through a wide array of paracrine signals acting at local or systemic level. Disturbance of cardiac homeostasis following ischemic injury also needs immediate response from these distant organs. Our hearts replace dead muscles with non‐contractile fibrotic scars. We have learned from animal models capable of scarless repair that regenerative capability of the heart does not depend only on competency of the myocardium and cardiac‐intrinsic factors but also on long‐range molecular signals originating in other parts of the body. Here, we provide an overview of inter‐organ signals that take part in development and regeneration of the heart. We highlight recent findings and remaining questions. Finally, we discuss the potential of inter‐organ modulatory approaches for possible therapeutic use. Abstract : Development and regeneration of the heart are processes controlled not only by intrinsic cardiac factors but also by molecular signals originating from other organs. While the former have been the focus of intense research, the importance of the latter has been recognized only more recently. In this review, we summarize the latest findings about the influence of inter‐organ communications in cardiac development and repair.