An Efficient Combinatorial Synthesis of Novel Thiazolidinone‐Bis Schiff Base Hybrids Using One‐Pot Multicomponent Reaction. Issue 2 (8th January 2023)

• Record Type: Journal Article
• Authors: Preeti, ; Jaiswal, Anjali; Kumar, Mahesh; Singh, Krishna Nand
• Is Part Of: Asian journal of organic chemistry. Volume 12:Issue 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-08
• Subjects: Bis-Schiff base hybrids -- Environmentally benign protocol -- Multicomponent reaction -- Thiazolidinone -- Unconventional Solvent; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202200629
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: A facile multicomponent synthesis of novel thiazolidinone‐bis Schiff base hybrids has been developed using readily available starting materials. The four‐component reaction of isothiocyanate, hydrazine, aldehyde and α‐bromoester in water readily affords thiazolidinone‐bis Schiff base hybrids, whereas the five‐component strategy involving the same reactants in the presence of boron trifluoride etherate in acetonitrile leads to the formation of the fully functionalized thiazolidinone‐bis Schiff base hybrids. Abstract : A facile multicomponent synthesis of novel thiazolidinone‐bis Schiff base hybrids has been developed using readily available starting materials. The four‐component reaction of isothiocyanate, hydrazine, aldehyde, and α‐bromoester in water readily affords thiazolidinone‐bis Schiff base hybrids, whereas the five‐component strategy with the same reactants in the presence of BF3 .Et2 O in acetonitrile leads to the formation of the fully functionalized thiazolidinone‐bis Schiff base hybrids.