Do Merkel complexes initiate mechanical itch?. Issue 2 (21st October 2022)
- Record Type:
- Journal Article
- Title:
- Do Merkel complexes initiate mechanical itch?. Issue 2 (21st October 2022)
- Main Title:
- Do Merkel complexes initiate mechanical itch?
- Authors:
- Bataille‐Savattier, Adeline
Le Gall‐Ianotto, Christelle
Lebonvallet, Nicolas
Misery, Laurent
Talagas, Matthieu - Abstract:
- Abstract: Itch is a common sensation which is amenable to disabling patients' life under pathological and chronic conditions. Shared assertion easily limits itch to chemical itch, without considering mechanical itch and alloknesis, its pathological counterpart. However, in recent years, our understanding of the mechanical itch pathway, particularly in the central nervous system, has been enhanced. In addition, Merkel complexes, conventionally considered as tactile end organs only responsible for light touch perception due to Piezo2 expressed by both Merkel cells and SA1 Aβ‐fibres ‐ low threshold mechanical receptors (LTMRs) ‐, have recently been identified as modulators of mechanical itch. However, the tactile end organs responsible for initiating mechanical itch remain unexplored. The consensus is that some LTMRs, either SA1 Aβ‐ or A∂‐ and C‐, are cutaneous initiators of mechanical itch, even though they are not self‐sufficient to finely detect and encode light mechanical stimuli into sensory perceptions, which depend on the entire hosting tactile end organ. Consequently, to enlighten our understanding of mechanical itch initiation, this article discusses the opportunity to consider Merkel complexes as potential tactile end organs responsible for initiating mechanical itch, under both healthy and pathological conditions. Their unsuspected modulatory abilities indeed show that they are tuned to detect and encode light mechanical stimuli leading to mechanical itch, especiallyAbstract: Itch is a common sensation which is amenable to disabling patients' life under pathological and chronic conditions. Shared assertion easily limits itch to chemical itch, without considering mechanical itch and alloknesis, its pathological counterpart. However, in recent years, our understanding of the mechanical itch pathway, particularly in the central nervous system, has been enhanced. In addition, Merkel complexes, conventionally considered as tactile end organs only responsible for light touch perception due to Piezo2 expressed by both Merkel cells and SA1 Aβ‐fibres ‐ low threshold mechanical receptors (LTMRs) ‐, have recently been identified as modulators of mechanical itch. However, the tactile end organs responsible for initiating mechanical itch remain unexplored. The consensus is that some LTMRs, either SA1 Aβ‐ or A∂‐ and C‐, are cutaneous initiators of mechanical itch, even though they are not self‐sufficient to finely detect and encode light mechanical stimuli into sensory perceptions, which depend on the entire hosting tactile end organ. Consequently, to enlighten our understanding of mechanical itch initiation, this article discusses the opportunity to consider Merkel complexes as potential tactile end organs responsible for initiating mechanical itch, under both healthy and pathological conditions. Their unsuspected modulatory abilities indeed show that they are tuned to detect and encode light mechanical stimuli leading to mechanical itch, especially as they host not only SA1 Aβ‐LTMRs but also A∂‐ and C‐fibres. … (more)
- Is Part Of:
- Experimental dermatology. Volume 32:Issue 2(2023)
- Journal:
- Experimental dermatology
- Issue:
- Volume 32:Issue 2(2023)
- Issue Display:
- Volume 32, Issue 2 (2023)
- Year:
- 2023
- Volume:
- 32
- Issue:
- 2
- Issue Sort Value:
- 2023-0032-0002-0000
- Page Start:
- 226
- Page End:
- 234
- Publication Date:
- 2022-10-21
- Subjects:
- alloknesis -- keratinocyte -- mechanical itch -- Merkel cell -- Merkel complex -- Piezo
Dermatology -- Periodicals
616.5 - Journal URLs:
- http://www.blackwellpublishing.com/journal.asp?ref=0906-6705&site=1 ↗
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0625 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/exd.14685 ↗
- Languages:
- English
- ISSNs:
- 0906-6705
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3839.070000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 25974.xml