Configuration‐Induced Multichromism of Phenanthridine Derivatives: A Type of Versatile Fluorescent Probe for Microenvironmental Monitoring. Issue 9 (24th January 2023)

• Record Type: Journal Article
• Authors: Huang, Wei; Feng, Shiyu; Liu, Jie; Liang, Baoshuai; Zhou, Ya; Yu, Mengya; Liang, Jiayuan; Huang, Jiaguo; Lü, Xujie; Huang, Weiguo
• Is Part Of: Angewandte Chemie international edition. Volume 62:Issue 9(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-24
• Subjects: Bioimaging -- Configuration-Induced Multichromism -- Microenvironmental Monitoring -- Optical Sensing -- Phenanthridine Derivatives; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202219337
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Fluorescent probes are attractive in diagnosis and sensing. However, most reported fluorophores can only detect one or few analytes/parameters, notably limiting their applications. Here we have designed three phenanthridine‐based fluorophores (i.e., B1, F1, and T1 with 1D, 2D, and 3D molecular configuration, respectively) capable of monitoring various microenvironments. In rigidifying media, all fluorophores show bathochromic emissions but with different wavelength and intensity changes. Under compression, F1 shows a bathochromic emission of over 163 nm, which results in organic fluorophore‐based full‐color piezochromism. Moreover, both B1 and F1 exhibit an aggregation‐caused quenching (ACQ) behavior, while T1 is an aggregation‐induced emission (AIE) fluorophore. Further, F1 and T1 selectively concentrate in cell nucleus, whereas B1 mainly stains the cytoplasm in live cell imaging. This work provides a general design strategy of versatile fluorophores for microenvironmental monitoring. Abstract : In sharp contrast to conventional fluorophores that can only detect one or few stimuli in microenvironments, a group of phenanthridine‐based fluorophores, namely B1, F1, and T1 with 1D, 2D, and 3D molecular configurations, respectively, have been developed. They show excellent capability in tracking a variety of stimuli through distinct fluorescence evolutions, thus offering promising applications in bioimaging, optical sensing, and many others.