Progress of Catalytic Mitsunobu Reaction in the Two Decades. Issue 2 (31st January 2023)

• Record Type: Journal Article
• Authors: Zhang, Kui; Chen, Yang; Song, Liangliang; Cai, Lingchao
• Is Part Of: Asian journal of organic chemistry. Volume 12:Issue 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-31
• Subjects: Mitsunobu reaction -- Redox-driven process -- Redox-neutral process -- SN2 reaction -- Stereo-inversion; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202200707
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: An important goal of modern synthetic chemistry is the development of highly efficient and selective processes that minimize the formation of waste, which are desirable for economy and environmental requirements. The classic Mitsunobu reaction has been adopted widely for converting alcohols into numerous functional groups and undergoes an inversion of stereochemistry in SN 2 reaction when secondary alcohols are employed. However, the reaction is far from ideal in terms of its environmental impact, requiring stoichiometric amounts of a phosphine (III) and an azodicarboxylate, and producing stoichiometric amounts of hydrazine and phosphine oxide wastes. The first attempt to access the catalytic Mitsunobu reaction dates back to 2006 by Toy's group and since then, several groups including Taniguchi, O'Brien, Aldrich, Denton and their co‐workers have opted for this promising alternative. Generally, the substantial progress has been made in the development of catalytic Mitsunobu reaction involving redox‐driven and redox‐neutral processes. The elegant redox‐driven catalytic system applies either external reductants or oxidants to recycle azo or phosphine reagents, while the preeminent redox‐neutral catalytic system is undergoing the activation step to proceed. This review summarizes the related developments in the recent two decades and presents the future research direction. Abstract : The reaction conditions of the catalytic Mitsunubo reaction are atom‐economic and "green". This review summarizes the advances in the field of the catalytic Mitsunobu reaction during the recent two decades and shed light on the rational design of the catalytic Mitsunobu reaction for the authors.