Assessment of neoadjuvant chemotherapy with docetaxel, cisplatin, and fluorouracil in patients with oral cavity cancer. (26th July 2022)

• Record Type: Journal Article
• Authors: Fu, Jin Ye; Yue, Xiu Hui; Dong, Min Jun; Li, Jiang; Zhang, Chen Ping
• Is Part Of: Cancer medicine. Volume 12:Number 3(2023)
• Page Start: 2417
• Page End: 2426
• Publication Date: 2022-07-26
• Subjects: neoadjuvant chemotherapy -- oral cavity cancer -- progression -- response rate -- survival -- TPF regimen; 616.994005
• DOI: 10.1002/cam4.5075
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Background: Chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) has been studied in patients with head and neck cancer. Its impact on patients with oral cavity cancer was not specified. Methods: We consecutively reviewed medical files of patients with untreated oral cavity cancer who received neoadjuvant TPF chemotherapy in our department from January 2017 to April 2020. Outcomes included the objective response to TPF chemotherapy, factors associated with the response, and progression and survival in different response groups. Results: A total of 167 patients were included, with half of stage IV disease. Complete or partial response was observed in 51 patients. A total of 91 patients had stable disease, and 25 patients had progressive disease. The response was not associated with age, sex, anatomic subsite, and the tumor's T stage. It was related with N stage ( p < 0.001) and clinical stage ( p = 0.004). Most patients with bulky nodes or nodes with obvious necrosis showed low response or even progressed after neoadjuvant TPF chemotherapy. The planned surgery was conducted in 159 patients. Disease relapse mostly occurred in 2 years after treatment. The 2‐year overall survival and the progression‐free survival were 89.0% and 85.2% for patients with complete or partial response, 62.4% and 55.6% for patients with stable disease, and 12.5% and 4.2% for patients with progressive disease, respectively. Conclusions: The response of neoadjuvant TPF chemotherapy in patients with oral cavity cancer is related to disease stage, especially the nodal stage. Patients with complete or partial response developed less progression events and better survival. Abstract : The response of neoadjuvant TPF chemotherapy in patients with oral cavity cancer was related to the disease stage, especially the nodal stage. Patients with bulky nodes or lymph node with obvious necrosis may have low response. Patients with complete or partial response developed less progression events and better survival.