Fifty years on: Serotonin and depression. (March 2023)

• Record Type: Journal Article
• Authors: Jauhar, Sameer; Cowen, Philip J; Browning, Michael
• Is Part Of: Journal of psychopharmacology. Volume 37:Number 3(2023)
• Page Start: 237
• Page End: 241
• Publication Date: 2023-03
• Subjects: Serotonin -- depression -- psychopharmacology -- learning -- positron emission tomography; Psychopharmacology -- Periodicals; 615.78
• DOI: 10.1177/02698811231161813
• Languages: English
• ISSNs: 0269-8811

Abstract

It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we summarise the evidence for the serotonin hypothesis of depression, focusing on psychopharmacology and molecular imaging, as well as systems-level neuroscience.