Penicillamine‐induced degenerative dermopathy in a patient with Wilson's disease. (24th December 2022)

• Record Type: Journal Article
• Authors: Chen, Yuting; Qiu, Yangyang; Chen, Meiqing; Jiang, Ying; Qiu, Xiaoyan; Gao, Lujuan
• Is Part Of: Australasian journal of dermatology. Volume 64:Number 1(2023)
• Page Start: 126
• Page End: 130
• Publication Date: 2022-12-24
• Subjects: degenerative dermopathy -- penicillamine -- Wilson's disease; Dermatology -- Periodicals; Dermatology -- Australasia -- Periodicals; 616.5005
• DOI: 10.1111/ajd.13963
• Languages: English
• ISSNs: 0004-8380

Abstract

Abstract: Penicillamine is a chelator that has been used in Wilson's disease, cystinuria, rheumatoid arthritis and heavy metal intoxication. We report a case of a 31‐year‐old man presented with skin atrophy, purpura and milia on the hips and shoulders after taking penicillamine for 1.5 years. According to literature review, this type of penicillamine‐associated cutaneous adverse effect belongs to degenerative dermopathy, which mostly occurs on bony prominences and points of pressure in patients with Wilson's disease or cystinuria. Withdrawal or reduction of drug dose can improve the features of degenerative dermopathy.