Efficacy and safety of lenvatinib in patients with recurrent hepatocellular carcinoma after liver transplantation. (5th August 2022)

• Record Type: Journal Article
• Authors: Bang, Kyunghye; Casadei‐Gardini, Andrea; Yoo, Changhoon; Iavarone, Massimo; Ryu, Min‐Hee; Park, Sook Ryun; Kim, Hyung‐Don; Yoon, Young‐In; Jung, Dong‐Hwan; Park, Gil‐Chun; Ahn, Chul‐Soo; Moon, Deok‐Bog; Hwang, Shin; Kim, Ki‐Hun; Song, Gi‐Won; Mazzarelli, Chiara; Alimenti, Eleonora; Chan, Stephen L.; De Giorgio, Massimo; Ryoo, Baek‐Yeol; Lee, Sung‐Gyu
• Is Part Of: Cancer medicine. Volume 12:Number 3(2023)
• Page Start: 2572
• Page End: 2579
• Publication Date: 2022-08-05
• Subjects: Albumin–bilirubin grade -- chemotherapy -- hepatocellular carcinoma -- lenvatinib -- liver transplantation; 616.994005
• DOI: 10.1002/cam4.5123
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Introduction: Lenvatinib is approved for the treatment of patients with metastatic or recurrent hepatocellular carcinoma (HCC); however, clinical outcomes of lenvatinib therapy in patients with post‐liver transplantation (LT) HCC recurrence remain unclear. We investigated the efficacy and safety of lenvatinib in patients with post‐LT HCC recurrence. Methods: This multinational, multicenter, retrospective study included 45 patients with recurrent HCC after LT who received lenvatinib at six institutions in three countries (Korea, Italy, and Hong Kong) from June 2017 to October 2021. Results: At the time of lenvatinib initiation, 95.6% ( n = 43) of patients had Child–Pugh A status, and 35 (77.8%) and 10 (22.2%) participants were classified as having albumin–bilirubin (ALBI) grades 1 and 2, respectively. The objective response rate was 20.0%. With a median follow‐up duration of 12.9 months (95% confidence interval [CI]: 11.2–14.7), the median progression‐free survival and overall survival (OS) were 7.6 (95% CI: 5.3–9.8) months, and 14.5 (95% CI: 0.8–28.2) months, respectively. Patients with ALBI grade 1 showed significantly better OS (52.3 months, [95% CI: not assessable]) than patients with ALBI grade 2 (11.1 months [95% CI: 0.0–30.4 months], p = 0.003). The most common adverse events were hypertension ( n = 25, 55.6%), fatigue ( n = 17, 37.8%), and anorexia ( n = 14, 31.1%). Conclusion: Lenvatinib showed consistent efficacy and toxicity profiles in patients with post‐LT HCC recurrence that were comparable to those reported from previous studies among non‐LT HCC patients. The baseline ALBI grade correlated with better OS in post‐LT lenvatinib‐treated patients. Abstract : Lenvatinib showed consistent efficacy and toxicity profiles in patients with post‐LT HCC recurrence that were comparable to those reported from previous studies among non‐LT HCC patients. The baseline ALBI grade correlated with better OS in post‐LT lenvatinib‐treated patients.