Mortality and causes of death in Crohn's disease: results from 20 years of follow-up in the IBSEN study. Issue 5 (6th June 2013)

• Record Type: Journal Article
• Authors: Hovde, Øistein; Kempski-Monstad, Iril; Småstuen, Milada Cvancarova; Solberg, Inger Camilla; Henriksen, Magne; Jahnsen, Jørgen; Stray, Njål; Moum, Bjørn A
• Other Names: Høie Ole author non-byline.; Sauar Jostein author non-byline.; Huppertz-Hauss Gert author non-byline.; Bernklev Tomm author non-byline.; Bengtson May-Bente author non-byline.; Vatn Morten author non-byline.; Opheim Randi author non-byline.; Aadland Erling author non-byline.; Flaaten Borgar author non-byline.; Kjellevold Øystein author non-byline.; Røseth Arne author non-byline.; Strøm Finn author non-byline.; Palm Øyvind author non-byline.; Lygren Idar author non-byline.; Lie Høivik Marte author non-byline.
• Is Part Of: Gut. Volume 63:Issue 5(2014)
• Page Start: 771
• Page End: 775
• Publication Date: 2013-06-06
• Subjects: Inflammatory Bowel Disorders -- Crohn'S Disease; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2013-304766
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Objective: Population-based studies have shown a slightly decreased life expectancy in patients with Crohn's disease (CD). The primary aim of the present study was to evaluate mortality and causes of death 20 years after the diagnosis in a well defined population-based cohort of CD patients in Norway. Design: The Inflammatory Bowel South-Eastern Norway study has prospectively followed all patients diagnosed with CD in the period between 1 January 1990 and 31 December 1993 in four geographically well-defined areas. All patients (n=237) were age and sex matched with 25 persons from the same county selected at random from the general population. Data on death and causes of deaths were collected from the Norwegian Causes of Death Register. All causes and cause-specific mortality (gastrointestinal cancer, cancer and heart disease) were modelled with Cox regression model stratified by matched sets. Results are expressed as HRs with 95% CIs. Results: There was no significant difference between CD patients and controls in overall mortality (HR=1.35, 95% CI 0.94 to 1.94, p=0.10). Furthermore, there were no marked differences in deaths from gastrointestinal cancer, other cancers or cardiovascular diseases in the CD group compared with the controls. In the CD group, 13.9% had died compared with 12.7% in the control group (p=0.578). Conclusions: In our population-based inception cohort followed for 20 years, there was no increased mortality or more deaths from cancer compared with the general population.