Anti-neuroinflammatory sesquiterpenoids from Chloranthus henryi. Issue 6 (19th March 2023)

• Record Type: Journal Article
• Authors: Wang, Xue-Jiao; Xin, Jun-Li; Yu, Sheng-Zhou; Pan, Li-Long; Hu, Jin-Feng; Xiong, Juan
• Is Part Of: Natural product research. Volume 37:Issue 6(2023)
• Page Start: 882
• Page End: 890
• Publication Date: 2023-03-19
• Subjects: Chloranthus henryi -- Chloranthaceae -- sesquiterpenoids -- anti-neuroinflammation; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2022.2095633
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Hupelactones A (1 ) and B (2 ), two new eudesmanolide-type enantiomers of the corresponding compounds, along with four mono- (3 –6 ) and nine dimeric- (7 –15 ) known sesquiterpenoids were isolated from the whole plant of Chloranthus henryi var. hupehensis (syn. C. henryi) . The new structures including the absolute configurations were determined by comparison with previously reported enantiomers, extensive spectroscopic methods in combination with electronic circular dichroism (ECD) calculations. All the isolates were evaluated for their inhibitory activities against the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in murine BV-2 microglial cells. Among them, the dimeric lindenane sesquiterpenoids shizukaols F (8 ) and G (11 ) exhibited the most potent activities, with IC50 values of 2.65 and 4.60 μM, respectively. Graphical Abstract: UF0001