Gender Difference in the Association of Hyperuricemia with Insulin Resistance and beta-cell Function in Nondiabetic Korean Adults: The 2019 Korea National Health and Nutrition Examination Survey. (2nd January 2023)

• Record Type: Journal Article
• Authors: Seong, Jeong Min; Gi, Mi Young; Cha, Ju Ae; Sung, Hyun Ho; Park, so Young; Park, Cho Hee; Yoon, Hyun
• Is Part Of: Endocrine research. Volume 48:Number 1(2023)
• Page Start: 1
• Page End: 8
• Publication Date: 2023-01-02
• Subjects: Hyperuricemia -- insulin resistance -- Beta-cell function -- gender difference -- nondiabetic; Endocrinology, Experimental -- Periodicals; Endocrinology -- Periodicals; Endocrinology -- Periodicals; Research -- Periodicals; 616.4
• DOI: 10.1080/07435800.2022.2142239
• Languages: English
• ISSNs: 0743-5800

Abstract

ABSTRACT: Aims: This study was conducted to assess the association of uric acid (UA) with the homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA- B ) by gender in nondiabetic Korean adults. Materials and Methods: The study was carried out using data from the 2019 Korean National Health and Nutrition Examination Survey and included nondiabetic Korean men, premenopausal women, and postmenopausal women aged 20 years or older. Results: First, after adjusted for the related variables (excluding obesity), the prevalence of hyperuricemia (UA ≥ 7.0 mg/dL in men or UA ≥ 6.0 mg/dL in women) was positively associated with the quartiles of HOMA-IR and HOMA- B in men, premenopausal women, and postmenopausal women. Second, when further adjusted for obesity, hyperuricemia was positively associated with the quartiles of HOMA-IR and HOMA- B in men and postmenopausal women but not in premenopausal women. Third, after adjusted for the related variables (including obesity), UA level was positively associated with the quartiles of HOMA-IR and HOMA- B in men and postmenopausal women but not in premenopausal women. Conclusions: hyperuricemia is positively associated with insulin resistance and beta-cell function in nondiabetic Korean men and postmenopausal women but not in premenopausal women.