Component analysis of Xylaria sp. L1 sporocarps after solid-state fermentation by okara and its safety evaluation in mice and rats. Issue 5 (4th March 2023)

• Record Type: Journal Article
• Authors: Liu, Guoqing; Wang, Zhihua; Cui, Xiaogang; Yang, Shaohua
• Is Part Of: Natural product research. Volume 37:Issue 5(2023)
• Page Start: 852
• Page End: 856
• Publication Date: 2023-03-04
• Subjects: Chemical component -- safety evaluation -- toxicology -- Zn supplementation; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2022.2092734
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: To explore the chemical components and nutrient components of Xylaria sp. L1 sporocarps, component analysis was characterized using UHPLC-LTQ-Orbitrap-MS/MS. Then, the acute toxicity and the subacute toxicity were conducted, respectively. A total of 38 compounds were detected and quantified. Meanwhile, Xylaria sp. L1 sporocarps had higher quantities of macronutrients, primarily Zn, which was remarkably higher than the human recommended daily values ( p < 0.001). Importantly, no evidence of toxicity was observed in the mice after acute exposure to Xylaria sp. L1 sporocarps. In subacute toxicity studies, there were no significant differences in the body and organ weights. In the blood chemistry analysis, no significant changes occurred. Pathologically, neither histopathological changes nor gross abnormalities were observed. Thus, our study highlights the potential for using Xylaria sp. L1 sporocarps as novel food with Zn supplementation for humans. Graphical Abstract: UF0001